Department of Biology

The Department of Biology offers both Ph.D. and Masters level graduate training in a variety of areas of specialization. These include Molecular Genetics, Cell & Developmental Biology; Ecology & Evolution; and Neurobiology & Behavior. In many cases, our research overlaps these categories. For example, Plant Biology can be found in both the Molecular Genetics, Cell & Developmental Biology and in the Ecology & Evolution subject areas. All of these areas offer exciting training opportunities, including participation in University institutes, multidisciplinary research groups and federally supported training programs.

Contact:
PO Box 400328
Charlottesville, VA 22904-4328
Phone: (434) 982-5474
Fax: (434) 982-5626
Website: http://www.virginia.edu/~biology/


    projects     |     faculty     |     news    


Projects By Department of Biology:

A Genetic Screen for Mutations Affecting Development of the Inner Ear of Xenopus Tropicalis
Noramly, Selina. Sponsor: Deafness Research Center
The focus of this project is to identify mutations affecting different aspects of ear development including induction of the otic placode, the formation and patterning of the otic vesicle, the formation ...

A Model of Circadian Disruption in the Space Environment
Menaker, Michael. Sponsor: National Space Biomedical Research Institute
We have developed a transgenic rat model that enables us to measure circadien rhythms of transcription of a "dock gene" (Perl) in the brain and in peripheral tissues. Using this model we have shown ...

A Model of Circadian Disruption in the Space Environment
Menaker, Michael. Sponsor: National Space Biomedical Research Institute
We have developed a transgenic rat model that enables us to measure circadian rhythms of transcription of a "clock gene" (Perl) in the brain and in peripheral tissues. Using this model we have shown that ...

A New Experiment Model for Cocaine's Effects on Cells
Cronmiller, Claire R. Sponsor: U.S. National Institute On Drug Abuse
The goal of this CEBRA proposal is to use Drosophila oogenesis to develop a new mode) experimental system to study the impact of cocaine on cells. Mammalian experimental models for studying cocaine's ...

Advanced Biotechnological Training for Implementation of MAS in the Genetic Improvement of Cowpea in Nigeria
Timko, Michael P. Sponsor: Kirkhouse Trust
From my training visit, I hope to receive extensive hands on experience in plant molecular and in particular marker development and use. I also hope to receive additional insight into current practices ...

Advanced Biotechnologies for Genetic Improvement of Cowpea in Sengal
Timko, Michael P. Sponsor: Kirkhouse Trust
Project Title: Advanced Biotechnologies for Genetic Improvement of Cowpea in Senegal - A Collaborative Student Training Program Project Goals and Objectives: The University of Virginia, in collaboration ...

Amphibian Model for Vertebrate Developmental Genetics
Grainger, Robert M. Sponsor: U.S. National Center For Research Resources
One of the most productive vertebrate developmental systems, the frog embryo has been the substrate for numerous embryological and molecular breakthroughs. This model currently lacks urgently-needed ...

Analysis Of Response Of Neurons In The Central Olfactory Pathway
Mellon, Deforest (Mike). Sponsor: U.S. Nsf - Directorate For Biological Sciences
The sense of smell is very important for behavior and food selection, but we still know very little about how olfactory information from the nose is handled by the brain. One model system that has ...

Animal Conservation
Gittleman, John L. Sponsor: Zoological Society Of London

Anther-smut as a Disease Model - Traversing Disciplines
Antonovics, Janis. Sponsor: U.S. Nsf - Directorate For Biological Sciences
This project will produce a book highlighting the past twenty-five years of NSF funded research of one group of scientists on a model host-pathogen system. This research has led to discoveries that ...

Assay for Genetic Differentiation in Spotted Marigined Madtoms Norturus Insignis
Kopeny, Mark T. Sponsor: Commonwealth Of Virginia
The Margin madtom, (Noturus insignis) is indigenous to the New River and to Atlantic coast drainages, where it is widely distributed from the Hudson River in New York to the Altahama River in ...

Assembly of Tau Filaments in Cultured Cells
Bloom, George S. Sponsor: U.S. National Institute On Aging

Assessment of the Aquatic Biota Prior to and Following Removal of the Woolen Mills Dam
Kopeny, Mark T. Sponsor: The Rivanna Conservation Society, Inc.
The Woolen Mills Dam is a stone block and timber crib dam six to ten feet high, spanning 270 feet across the Rivanna River in Albemarle County adjacent to Charlottesville, Virginia. In 2001, the Rivanna ...

Augmentation Awards For Science & Engr. Res. Train
Block, Gene D. Sponsor: U.S. Dod - Air Force - Afosr
Support is requested for two graduate students (both women) to work towards Ph.D. degrees in the Department of Biology (Ms. Cara Constance) and in the Neuroscience Program and Department of Biology ...

Behavior Regulation of Neuroendocrine Cells
Rissman, Emilie F. Sponsor: U.S. National Institute Of Mental Health
The long range goal of this research is to understand how social cues and behavioral experience affect neuronal functioning. The research proposal included examination of three aspects of gonadotropin ...

Behavioral Regulation of Neuroendocrine Cells
Rissman, Emilie F. Sponsor: U.S. National Institute Of Mental Health
The long range goal of this research is to understand how social cues and behavioral experience affect neuronal functioning. The research proposal included examination of three aspects of gonadotropin ...

Cdc42p-Dependent Organization of the Cytoskeleton
Keller, Raymond E (Ray). Sponsor: Leukemia & Lymphoma Society

Cell Mobility and Cell Interactions During Neurulation
Keller, Raymond E (Ray). Sponsor: National Institute of Child Health and Human Devel
The broad objective of the proposed research is to describe the embryonic cell motility that shapes the early nervous system. The specific goals are to describe the types of neural cell motility that ...

Cell Motility and Cell Interactions During Neurulation
Keller, Raymond E (Ray). Sponsor: U.S. Nih Of Child Health & Human Development
The broad aim of this project is to determine the tissue interactions and signaling pathways that control a specific type of polarized cell motility that occurs during "convergence and extension" (narrowing ...

Cell-Specific Ablation of Circadian Clock Function in V
Green, Carla B. Sponsor: Jeffress Memorial Trust
The vertebrate retina depends on precise temporal control of many aspects of its physiology in order to respond to huge changes in ambient light levels over the course of the 24 hour day. Endogenous ...

Cellular Basis of Circadian Rhythms in Mammals
Block, Gene D. Sponsor: U.S. National Institute Of Mental Health
The isolated eyes of several marine mollusks express circadian rhythms in spontaneous optic nerve impulse frequency. In Bulla gouldiana the ocular rhythm is generated by a group of approximately ...

Cellular Control of Folate Uptake: Caveolae v Coated Pi
Bloom, George S. Sponsor: U.S. Nih Diabetes & Digestive & Kidney Diseases
The long range objective of this proposal is to learn how cells exploit receptor-mediated potocytosis to regulate folate accumulation. The health relatedness of this objective is based on the observations ...

Chemical & Genetic Manipulation of Circadian Systems
Green, Carla B. Sponsor: Northwestern University
Although many components of the central clock mechanism have been identified, very little is known about the biochemical details of their action. Target validation for small molecule screens will be ...

Circadian Gene Control of Cocaine Response in Drosophila Melanogaster
Hirsh, Jay. Sponsor: U.S. National Institute On Drug Abuse
Cocaine use is a serious health problem in the USA. Previous work has demonstrated that Drosophila melanogaster responds to cocaine with locomotor responses similar to rodents. Using flies, it has ...

Circadian Organization in the Aged Rodent
Block, Gene D. Sponsor: U.S. National Institute On Aging
My goal in this fellowship is to investigate the mechanisms by which circadian rhythms break down during the aging process. The central circadian pacemaker in the rat suprachiasmatic nucleus entrains ...

Circadian Oscillators in Cultured Mammalian Retina
Menaker, Michael. Sponsor: U.S. National Institute Of Mental Health
Our long term goals of the project are to understand the mechanism that generates circadian rhythmicity in the retina, and elucidate the rote played by rhythmic synthesis of melatonin in retinal function. ...

Circadian Post-transcriptional Regulatory Mechanisms
Green, Carla B. Sponsor: U.S. National Institute Of General Medical Science
Circadian clocks are intracelluler timekeeping mechanisms that allow cells to coordinate various aspects their physiology with time of day. These clocks are self-sustained oscillators with periods ...

Coll Res: Independent Evolutionary Origins of Tetrodotoxin Resistance as a Test of the Geographic Mosiac of Coevolution
Brodie, Edmund Darrell III (Butch). Sponsor: U.S. Nsf - Directorate For Biological Sciences
The primary goals of this award were (1) to investigate the pattern of TTX toxicity in newt populations and the associated TTX resistance in sympatric species of snakes throughout a region where multiple ...

Collaborative Research: Structural Determinants of Catalysis and Allosteric Regulation in DAHP Synthase
Bauerle, Ronald H. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Mutational and biochemical studies will be combined to define the structural basis for catalytic activity and feedback regulation in the 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) isozyme ...

Collaborative Research: Phylogenetic Analysis of G-matrix Evolution
Brodie, Edmund Darrell III (Butch). Sponsor: U.S. Nsf - Directorate For Biological Sciences
The primary goals of this award are to establish breeding colonies of multiple species of Anolis lizards for the purpose of comparing genetic variance-covariance ("G") matrices within and among repeated ...

Collaborative Research: The Evolutionary Genetics of Invasiveness in Silene Iatifolia
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Biological invasions represent one of the greatest threats to the preservation of biodiversity. In addition, the economic costs to the USA resulting from damage and control of alien organisms (e.g....

Contribution of Genetic & Environmental Maternal Effect
Galloway, Laura F. Sponsor: U.S. National Science Foundation
Maternal environments may influence the expression of traits in their offspring. These maternal effects can alter evolutionary change in response to selection, creating lag times, negative or cyclical ...

Contribution of Genetic & Environmental Maternal Effects to Life History Evolution
Galloway, Laura F. Sponsor: U.S. Nasa - Goddard
Maternal environments may influence the expression of traits in their offspring. These maternal effects can alter evolutionary change in response to selection, creating lag times, negative or cyclical ...

Daniel Sloan Dissertation Research: The Effect of Mutation Rate on Mitochondrial Genome Evolution in the Angiosperm Genus Silene
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences

Determinants of Virulence & Host Specificity in the Parasitic Angiosperm Striga Gesnerioides
Timko, Michael P. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Parasitic angiosperms are a major constraint to crop and forest productivity world-wide. Among the most agronomically important parasites are the witchweeds (Striga spp.) because their hosts are subsistence ...

Develop New Protein-Based Biomaterials
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)
The general goal of this project is in initiation work towards developing new protein-based biomaterials having self-assembling functional nanostructures. Specifically, the target is to identify mechanisms ...

Development of a Holographic Fluorescence Microscope
Bloom, George S. Sponsor: Johns Hopkins University
Green fluorescent protein (GFP), and variants, can be expressed in cells as chimeras, linked to target proteins of biological importance. These fluorescent protein construct probes, and other organic ...

Development of Building Blocks to Prescribe Ecological Flows for the Rivanna River Watershed
Kopeny, Mark T. Sponsor: The Nature Conservancy
The Rivanna River system serves as the water supply source for the City of Charlottesville, VA and much of Albemarle County, VA. A complex system of reservoirs, river intakes, transmission pipes, ...

Development of New Protein Based Biomaterials
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)
The general goal of this project is in initiation work towards developing new protein-based biomaterials having self-assembling functional nanostructures. Specifically, the target is to identify mechanisms ...

Development of New Protein Based Biomaterials
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)

Development of New Protein Based Biomaterials
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)
The goal of the proposed efforts is in understanding principles and evaluating the possibility for the construction of innovative light energy converting devices based on biological material (photosynthetic ...

Development of New Protein Based Biomaterials
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Other

Development of New Protein Based Biomaterials
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)

Direct Interactions Between Alz & Tau in Cultured Cells
King, Michelle E. Sponsor: Virginia Commonwealth University
Extracellular accumulations of Alz-amyloid fibrils and intracellular accumulations of tau filaments are the two pathological hallmarks of Alzheimer's Disease. A number of laboratories have provided ...

Direct Nanoscale Conversion of Bio-Molecular Signals into Electronic Information
Lebedev, Nikolai. Sponsor: Brown University
The main goal of Dr. Lebedev's work will be in integration of photosynthetic reaction centers (RCs) as photo-switchable elements in multiprotein detection system. That will allow for control of the ...

Disease on New Hosts-Microbotryum as a Model System
Antonovics, Janis. Sponsor: U.S. National Institute Of General Medical Science
Host shifts of pathogens from animal species have lead to an increasing number of infectious diseases in humans. Studies of host shifts have been conducted primarily through the historical approach ...

Dissertation Research: Symbiont Evolution & Host Social Structure: Bees & Nematodes
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences

Early Development of the Zebrafish Forebrain
Ungar, Ann. Sponsor: Whitehall Foundation
The goal of my work is to understand how cells in the developing brain know where they are and what to become. Recent work suggests roles for several cell-cell signaling factors in patterning the developing ...

Ecology and Genetics of Male/Female-Ratio Polymorphism in Natural Populations of the <i>Silene Latifolia </i>
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences
So-called 'selfish genetic elements' are genes that enhance their own transmission across generations at the expense of the organism in which they reside. Often, there are other genes that suppress ...

Ecology, Evolution & Behavior Field Research at Mt. Lake Biological Station
Nagy, Eric S. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The Mountain Lake Biological Station (MLBS) was founded in 1929 as a teaching, and research facility of the Biology Department of the University of Virginia. It is located on a mountaintop in the Appalachian ...

Electronic Biochemistry - An Interactive E-Book Version of an Existing Biochemistry Textbook
Garrett, Reginald H. Sponsor: U.S. Nsf - Directorate For Ed. & Human Resources
The Electronic Biochemistry e-book is a fully interactive, digital resource that transcends the limitations of the two-dimensional printed page ...

Energetic Regulation of Puberty
Rissman, Emilie F. Sponsor: U.S. Nsf - Directorate For Biological Sciences
An important compound involved in reproduction in all vertebrate species is gonadotropin-releasing hormone, GnRH. This peptide is produced in nerve cells of the brain, and regulates synthesis and release ...

Epigenetics Affecting Cellular Heterogeneity in Neuroblastoma
Henriksen, Melissa Ann. Sponsor: Jeffress Memorial Trust

Evolution at the Edge
Galloway, Laura F. Sponsor: Jeffress Memorial Trust
Understanding what determines a species range is a major goal of Evolutionary Biology and Ecology. There is a growing consensus that hybridization is important to range expansion. Hybridization between ...

Evolution In Vitro Engineering the Active Site of an En
Kretsinger, Robert H. Sponsor: Jeffress Memorial Trust
Studies of the molecular evolution of two paralogous enzymes from E.coli, 3-deoxy-Darabino-heptulosonate-7-phosphate synthase (DAHPS) and 3-deoxy-D-rnanno-octulosonate-8- phosphate synthase (KDOPS), ...

Evolution in vitro: Structures of DAHPSynthase*KDOPSynthase Chimeras
Kretsinger, Robert H. Sponsor: U.S. Nsf - Directorate For Biological Sciences
This project focuses on structural studies designed to reveal the mechanisms of action and of regulation of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) and 3-deoxy-D- manno-2-octulosonate-8-phosphate ...

Evolution of Reproductive Strategies
Wilbur, Henry M. Sponsor: U.S. Nsf - Directorate For Biological Sciences
When studying the evolution of reproductive strategies, or the collection of traits that contribute to reproduction, it is necessary to study how correlated traits respond to the same selective regime. ...

Experimental & Investigative Laboratory Courses in Evolutionary Biology
Antonovics, Janis. Sponsor: U.S. Nsf - Directorate For Ed. & Human Resources
Over the past twenty years, evolutionary biology has developed in to a vibrant, investigative science with a potent relevance to societal issues such as origins of infectious disease and biotechnology. ...

Extramural Research Facilities Construction
Hornberger, George M. Sponsor: U.S. National Center For Research Resources

Extramural Research Facilities Construction
Hornberger, George M. Sponsor: U.S. National Center For Research Resources
The long-term objective of this proposai is to enhance the biomedical research capabilities in molecular and cellular biology in the Department of Biology and the University of Virginia. Specific ...

Fabrication of Photoactive Bio-inorganic Surfaces
Lebedev, Nikolai. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)
In the last year, substantial progress has been achieved in the fabrication of photoactive bio-inorganic surfaces that can be used for the construction of innovative photosensors and photovoltaic devices. ...

Faculty and Student Housing Improvements at Mountain Lake Biological Station
Brodie, Edmund Darrell III (Butch). Sponsor: U.S. Nsf - Directorate For Biological Sciences

Fsml: Computer Network Installation & Housing
Wilbur, Henry M. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Mountain Lake Biological Station was founded in 1921 as an inland field station for and teaching in the Southern Appalachians. In the last twenty years the research program has developed a focus in population ...

Function of Novel CDC42-Interacting Genes in Polarized Morphogenesis
Kozminski, Keith G. Sponsor: March Of Dimes
Asymmetrically structured cells are critical for the function of tissues involved in vectored processes such as nutrient transport, neuronal signaling, and secretion. Mutations that disrupt the development ...

Functional Studies of Biogenic Amines
Hirsh, Jay. Sponsor: U.S. National Institute Of General Medical Science
This proposal uses the fruit fly, Drosophila melanogaster, as a model to study the pathways regulating responses to free base "crack" cocaine. This model organism shows conservation with vertebrate ...

G Protein Mediated Control of the Neuronal Cytoskeleton
Bloom, George S. Sponsor: U.S. National Institutes Of Health
The outgrowth of nerves during early development and regeneration depends upon reorganization of actin filaments at nerve endings. This process is controlled in part by "G proteins", which become activated ...

Gene Regulation by a Photoreceptor Circadian Clock
Green, Carla B. Sponsor: U.S. National Eye Institute
The vertebrate retina changes many aspects of its physiology with respect to time of day, which allows the retina to adapt efficiently to varying light intensities of many orders of magnitude. These ...

Genetic & Evolutionary Consequences of Intra-Tetrad Selfing in the Anther-Smut Fungus
Antonovics, Janis. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Populations of the anther-smut pathogen contain high frequencies of individuals that produce gametes of only one mating type. even though both mating types are required for conjugation and infection. ...

Genetic & Neuroendocrine Control of Behavioral Systems
Rissman, Emilie F. Sponsor: U.S. National Institute Of Mental Health
Determine if elevated levels of testosterone can activate normal sexual motivation and copulatory performance in WT, LIET, and ERaKO males. Assess the role of ERs, other than ERa, in the organization ...

Genetic Analysis of Follicle Formation During Drosophila Oogenesis
Cronmiller, Claire R. Sponsor: Jeffress Memorial Trust
Serotonin and serotonergic neurons are thought to play a critical role in the development oldie central nervous system (CNS). Extracellular serotonin levels arc. regulated by the serotonin transporter, ...

Genetic Analysis of Prehair Morphogenesis
Adler, Paul N. Sponsor: U.S. National Institute Of General Medical Science
Many cell types are highly asymmetric and produce prominent extensions (e.g. microvilli). This is common for epithelial cells (e.g. intestinal brush border cells), which typically produce them from ...

Genetic Control of Early Retinal Development
Grainger, Robert M. Sponsor: U.S. National Eye Institute
The earliest processes leading to the formation of the retina remain poorly understood. It is the goal of this proposal to gain significant understanding of the mechanisms leading to determination ...

Genetic Control of Lens Formation
Grainger, Robert M. Sponsor: U.S. National Eye Institute
Three specific aims are being pursued in our studies of gene regulation during retina and lens formation. First we are continuing our analysis of crystallin gene regulation during lens formation in ...

Genetic Control of Tissue Polarity
Adler, Paul N. Sponsor: U.S. National Institute Of General Medical Science
Our long-term goal is to understand the genetic control of morphogenesis at the interface between the cellular and tissue levels. We use planar polarity in the Drosophila wing as a model system. ...

Genetic Determinants of Brain Sexual Differentiation
Rissman, Emilie F. Sponsor: University Of California at Los Angeles
The long term goal of the proposed studies is to understand the molecular signals that initiate sexually dimorphic development of the brain, and lead to sex differences in behavior. A great deal of ...

Genomic Approaches for Reducing Harm by Modification of Tobacco Leaf Composititon and Chemistry
Timko, Michael P. Sponsor: PHILLIP MORRIS USA

Genomics and the Evolution of Sexual Systems: Developing Silene and Microbotryum as Model Organisms
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Genes on autosomes, on sex-chromosomes, in mitochondria and chloroplasts, and those associated with transposable elements are inherited through different pathways and with different rules. Yet the ...

GEPR: The Parasitic Plant Genome Project
Timko, Michael P. Sponsor: Virginia Tech
Parasitic plants are benchmark organisms in plant evolution. Evolutionary pressures of a parasitic life have resulted in anatomical and physiological alterations unknown in nonparasitic autotrophic ...

Global Changes in Gene Expression During Sensitization
Hirsh, Jay. Sponsor: U.S. National Institute On Drug Abuse
Our genetic studies of cocaine responsiveness in the fruit fly (Drosophila melanogaster) will provide basic mechanistic information that is currently unattainable in higher organisms. The sorts ...

Global Geographic Ranges in Mammals: A Complete Database
Gittleman, John L. Sponsor: Conservation International Fdn.
Why species inhabit certain areas rather than others is critical to understanding and preserving biodiversity. Species differences in geographic ranges signify patterns of rarity, extinction, species ...

Hematopoietic Circadian Rhythms
Menaker, Michael. Sponsor: Roger Williams Hospital
Most biological systems show circadian rhythms probably regulated by signals from the suprachiasmatic nucleus (SCN) in the hypothalmus. Flematopoietic rhythms have been identified for different progenitor ...

Hematopoietic Circadian Rhythms
Menaker, Michael. Sponsor: Roger Williams Hospital
Most biological systems show circadian rhythms probably regulated by signals from the suprachiasmatic nucleus (SCN) in the hypothalmus. Hematopoietic rhythms have been identified for different progenitor ...

Hotspots for Global Bat Conservation Priorities: Maximising Tomorrows Biodiversity
Gittleman, John L. Sponsor: Bat Conservation International, Inc.
Biodiversity loss is one of the world's most pressing crises. Over a half of the 916 species of bats on our planet are classified as threatened or near threatened with extinction. Limited resources ...

Identification of Osmoregulatory Mutants in Drosophila
Blumenthal, Edward M. Sponsor: U.S. Nih Diabetes & Digestive & Kidney Diseases
Disorders affecting kidney function are a serious health problem with significant human and economic costs to society. An important step toward the goal of reducing the impact of renal disease is an ...

Identifying the Genes Controlling Melanin Production
Taylor, Douglas R. Sponsor: Jeffress Memorial Trust
Melanism, or dark pigmentation, is found in virtually all animal taxa. Both adaptive melanic morphs (e.g. peppered moths) and those maintained by recurrent, deleterious mutations (e.g. Lepidopteran ...

In vivo Studies of Vertebrate Circadian Clock Genes
Provencio, Ignacio (Iggy). Sponsor: U.S. National Institute Of Mental Health
Circadian clocks control many processes important for normal functioning of living organisms, including behavior, physiology and biochemistry. These clocks are endogenous timekeeping devices and have ...

In Vivo Studies of Vertebrate Circadian Clock Genes
Green, Carla B. Sponsor: U.S. National Institute Of Mental Health
Circadian clocks control many processes important for normal functioning of living organisms, including behavior, physiology and biochemistry. These clocks are endogenous timekeeping devices and have ...

Induction of the Embryonic Lens
Grainger, Robert M. Sponsor: U.S. National Eye Institute
The specific aims of this project art 1) to clarify key tissue interactions regulating lens determination in Xenopus; 2) to initiate studies of mouse lens induction, with a focus on Smalleye mice (mutated ...

Information Processing in the Electrosensory System
Kawasaki, Masashi. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Certain fish known as weakly electric fish produce motor commands that do not activate muscles, but produce a regularly repeated discharge from small electric organs in the body, and they have electroreceptor ...

Intestinal Parasites, Acorn Masts, and Population Dynamics of Peromyscus
Antonovics, Janis. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Infectious disease may substantially impact the health and stability of natural animal populations. White-footed mouse (Peromyscus leucopus) and deer mouse (P. maniculatus) populations have been found ...

Investigation of Early Forebrain Development by Use of Stable Transgenic Frog Lines
Grainger, Robert M. Sponsor: U.S. Civilian Res. & Development Fdn.
While scientists have in recent years gained a better general understanding about how the anterior to posterior axis of vertebrate embryos is established--a very significant achievement-very little is ...

Karyotype Dynamics & Automixis In Microbotryum
Hood, Michael E. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Unlike most organisms where the structure of the chromosomes (the karyotype) is relatively stable, in the fungus Microbotryum there is enormous variation in chromosome size and the DNA content from ...

MAP Based Cloning of Cowpea RSG Genes Encoding
Timko, Michael P. Sponsor: U.S. Agency For International Development
At present maize cultivars immune to Striga hermonthica do not exist. Several maize varieties have been found that show increased levels of tolerance to S. hermonthica parasitism. These ...

Map Based cloning of Nic1 & Nic2; Nuclear Genes involved in Global regulation of Alkaloid Biosynthesis and Tobacco
Timko, Michael P. Sponsor: Philip Morris
The biosynthesis of alkaloids in most vascular plants, including tobacco (Nicotiana tabacum L.), is a developmentally regulated process involving differential gene expression in specific tissues ...

Marker Development & Marker-Assisted Selection for Striga Resistance in Cowpea
Timko, Michael P. Sponsor: International Institute of Tropical Agriculture
Cowpea is grown on 9.8 million hectares of small farms in the dry savannah of tropical Africa and is an important food grain for over 200 million people in this region. Current estimates place world ...

Max-Planck Institute for Demographic Research (MPIDR)
Roach, Deborah A. Sponsor: Max-Planck-Institut fur demografische Forschung
Measurements of photosynthesis and transpiration in plants of a natural population of Plantago lanceolata to assess links between physiological and demographic approaches to aging. The traits ...

Max-Planck Institute for Demographic Research (MPIDR) #2
Roach, Deborah A. Sponsor: Max-Planck-Institut fur demografische Forschung
Measuring physiological and demographic aging of individual plant leaves on plants of different ages in an already ongoing experiment. The sampling will include 80 individuals each from cohorts #1 ...

Max-Planck Institute for Demographic Research (MPIDR)#3
Roach, Deborah A. Sponsor: Max-Planck-Institut fur demografische Forschung
Measuring physiological and demographic aging of individual plant leaves on plants of different ages in an already ongoing experiment. The sampling will include 80 individuals each from cohorts #1 ...

Mechanism of Anti-Capping by ENA-VASP Proteins
Schafer, Dorothy. Sponsor: Jeffress Memorial Trust
Cell motility is a highly regulated process involving many cellular factors. The Ena/vasodilator-stimulated phosphoprotein (VASP) protein Family regulates several actin- dependent motile processes, ...

Mechanisms of Actin Assembly at Membranes
Schafer, Dorothy. Sponsor: U.S. National Institute Of General Medical Science
The long-term objectives of this research are to elucidate the functions carried out by actin filaments during membrane traffic and to determine the mechanisms whereby actin filaments provide those ...

Mechanisms of Early Forebrain Development in Xenopus
Grainger, Robert M. Sponsor: U.S. Civilian Res. & Development Fdn.
Despite impressive progress achieved in the last few years by functional genomics, the genetic mechanisms underlying early development of the vertebrate brain still be insufficiently understood because ...

Microsecond Processing by Weakly Electric Fish
Kawasaki, Masashi. Sponsor: Japan Science And Technology Corp
The broad, long-term objective of this proposal is to understand neuronal mechanisms by which animals process sensory information and accordingly generate adaptive behaviors. Of particular interest ...

Molecular Genetic Analysis Of Morphogenesis
Cronmiller, Claire R. Sponsor: Jeffress Memorial Trust

Molecular Mechanisms of Neurite Morphogenesis
Condron, Barry G. Sponsor: Keck Foundation
One of greatest challenges remaining for modern science is to understand how neurons form precise connected networks in the brain. Understanding the formation of connections in the brain will greatly ...

Mortality & Morbidity Associated with Phase-Shifts of the Lighting Environment
Menaker, Michael. Sponsor: Morehouse School Of Medicine

Multiphoton Spectral Imaging Microscopy
Periasamy, Ammasi. Sponsor: U.S. National Center For Research Resources
The W.M. Keck Center for Cellular Imaging (KCCI) is one of the leading centers in the advanced light microscopy imaging, particularly in protein-protein interactions imaging, requesting a Zeiss "Multiphoton ...

Neural Basis of Circadian Organization
Block, Gene D. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
The isolated eyes of several marine mollusks express circadian rhythms in spontaneous optic nerve impulse frequency. In Bulla gouldiana the ocular rhythm is generated by a group of approximately ...

Neural Basis of Mammalian Circadian Organization
Block, Gene D. Sponsor: U.S. National Institute Of Mental Health
The suprachiasmatic nucleus ( SCN ) of the mammalian hypothalamus is part of the system that controls the near 24-hour (Circadian) rhythms in many physiological processes and behaviors. This timing ...

Neural Basis of Mammalian Circadian Organization
Block, Gene D. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Dr. Gabriella Lundkvist, Department of Neuroscience, Karolinska Institutet, Stockholm, will coordinate research on the project at Karolinska Institutet. Dr. Lundkvist has extensive experience with photometric ...

Neuronal Control of Animal Movements
Friesen, Wolfgang O (Otto). Sponsor: U.S. Nsf - Directorate For Biological Sciences
Animals initiate voluntary movements either in response to specific stimuli or as autonomous actions arising from an internal change in state. The research project proposed here is designed to further ...

Neuronal Organization for Electromotor Behaviors
Kawasaki, Masashi. Sponsor: U.S. Nsf - Directorate For Biological Sciences
In the brain, the process of sensory-motor integration produces behavioral outputs that are generated as a result of sensory computation and orchestration of motor commands. In animals with complex brains, ...

New Strategies for Understanding Fore brain Development; by use of stable transgenic frog & novel fluorescent reporter proteins
Grainger, Robert M. Sponsor: U.S. John E. Fogarty International Center
Investigation of the forevbrain development is an important goal of modern developmental biology as the molecular mechanism underlying the development of this paramount part of the Central Neural System ...

Non-Invasive Self Administration Methodology for Mice
Hirsh, Jay. Sponsor: U.S. National Institutes Of Health
When humans use cocaine, they generally snort it through their nose. This method of cocaine use is quite different from the methods currently used in animal research. In all animal models of cocaine ...

Nuclear Factors Regulating Plastid Gene Expression in Light-Independent Chlorophyll Formation in <i>Chlamydomonas</i>
Timko, Michael P. Sponsor: U.S. Nsf - Directorate For Biological Sciences
During evolution two distinct mechanisms were established for the reduction of protochlorophyllide (pchlide) to chlorophyllide (chlide), a key step in the chlorophyll biosynthesis pathway. One mechanism, ...

Ovarian Follicle Morphogenesis in Drosophila
Cronmiller, Claire R. Sponsor: U.S. Nsf - Directorate For Biological Sciences
During reproduction in most animals, oogenesis is a multicellular process that appears to require complex patterns of intercellular communication to promote the growth and differentiation of the mature ...

Oxysterol Binding Proteins in Polarized Morphogenesis
Kozminski, Keith G. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The ability to rationally modulate the growth and specialization of cells or protocells requires knowledge of how cells grow in an asymmetric or polarized manner. Polarized cell growth is a process essential ...

Parasite Biodiversity and Disease Risk in Wild Mammals
Gittleman, John L. Sponsor: University of Georgia
What is the global distribution of parasite risk? Using GIS and the information on locality in our comparative databases, we will develop protocols to identify parasite biodiversity hotspots, areas ...

Peripheral Sensory System
Grainger, Robert M. Sponsor: U.S. Nih Deafness & Other Communication Disorders
The long-term goal of this Program Project Grant (PPG) is to examine common and unique processes during development and regeneration of sensory receptor cells in related sensory systems. Specifically, ...

Photic Regulation of Circadian Rhythms
Provencio, Ignacio (Iggy). Sponsor: U.S. Nih Of Neurological Disorders & Stroke
The effects of blindness on the independence and productivity of afflicted individuals are profound. Although the loss of vision is the primary culprit, concomitant deficits in the regulation of non-visual ...

Physiology and Function of Sensory Feedback Loops
Friesen, Wolfgang O (Otto). Sponsor: U.S. Nsf - Directorate For Biological Sciences
Animal locomotion results from the intricate interplay between connections within the nervous system and sense organs that monitor the execution of commands from the central nervous system. For animals ...

Plasticity of Mammalian Circadian Axis
Menaker, Michael. Sponsor: U.S. National Institutes Of Health
The overall aim of the proposed work is to understand plasticity in two central components the mammalian circadian system; the pineal gland,and the suprachiasmatic nucleus (SCN). In the case ...

Plasticity of Mammalian Circadian Axis
Menaker, Michael. Sponsor: Morehouse School Of Medicine
Serotonin plays an important but poorly understood role in the circadien visuel system in mammals. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus, thought to be the master pacemaker, and ...

Poly(A) Removal & Translational Silencing of Maternal mRNAs
Wormington, W M (Michael). Sponsor: U.S. Nsf - Directorate For Biological Sciences
Oocytes synthesize and accumulate a large pool of maternal mRNAs. Some of these are actively translated throughout oogenesis while others remain quiescent until they are activated or "unmasked" at ...

Poly(A) Removal and Translational Silencing of Maternal mRNAs
Wormington, W M (Michael). Sponsor: U.S. Nsf - Directorate For Biological Sciences
Oocytes synthesize and accumulate a large pool of maternal mRNAs. Many of these transcripts are actively utilized for protein synthesis throughout oogenesis, but are subsequently silenced when the oocyte ...

Population Dynamics in Variable Environments
Wilbur, Henry M. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Three mechanisms that promote the persistence of populations in uncertain environments are: 1) a variable age at maturation, 2) repeated reproduction, and 3) dispersal between populations. The project ...

Population Dynamics in Variable Environments
Wilbur, Henry M. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Population dynamics in spatially and temporally varying environments comprise an important area of population biology because they determine the context of life history adaptation and population differentiation. ...

Population Dynamics in Variable Environments
Taylor, Douglas R. Sponsor: U.S. National Science Foundation

Postdoctoral Fellowship on Behalf of J.A. Mohawk
Menaker, Michael. Sponsor: U.S. National Institute On Drug Abuse
The prevalence of drug abuse in the United States, and the health risks it imposes, makes it increasingly critical to examine the factors influencing sensitivity to drugs of abuse. One such factor is ...

Predator-Prey Interaction in Aquatic Foodwebs
Wilbur, Henry M. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Species interactions are a major factor determining the structure and dynamics of ecological communities. Cannibalism is a unique ecological interaction that creates a trophic structure within populations ...

Protein Structure in Catalytic Function of NADPH: PROTOCHLOROPHYLLIDE OSIDOREDUCT ASES
Timko, Michael P. Sponsor: U.S. Department Of Energy - Chicago
Chlorophylls play a fundamental role in the energy absorption and transduction activities of all photosynthetic organisms. In cyanobacteria, green algae, and most vascular plants chlorophyll formation ...

Regulating the Cocaine-Sensitive Serotonin Transporter
Condron, Barry G. Sponsor: U.S. National Institute On Drug Abuse
The expression of the cocaine-sensitive serotonin transporter (SerT) is regulated in a complex manner in the developing central nervous system (CNS). Mutations that alter expression of SerT ...

Regulating the Fate of Serotonergic Neurons
Condron, Barry G. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
During the period of 1999-present, two papers have been published directly from this study, one in Neuron and one in Development. The basic focus of the lab has switched slightly in that we are now using ...

Regulation of Actin Assembly & Cell Motility by IQGAPs
Bloom, George S. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
The overall goal of this application is to determine how IQGAPI and other mammalian IQG regulate actin filament nucleation by the Arp2/3 complex, and by extension, cellular motility. In multicellular ...

Regulation of Cytoskeleton & Membrane Traffic by P22
Barroso, Margarida M (Guida). Sponsor: U.S. National Institute Of General Medical Science
One of the most challenging aspects of cell biology addresses the question of how the cytoskeleton participates in the delivery of carrier vesicles between organelles and from these to the plasma membrane. ...

Regulation of Polarized Morphogenesis: Functional Analysis of Zds2p in S. Cerevisiae
Kozminski, Keith G. Sponsor: Jeffress Memorial Trust
Human development, immunity, wound healing, and nutrient uptake all depend upon the ability of cells to change shape. Acquisition of an asymmetric or polarized morphology by a cell is especially critical ...

Renovations
Kawasaki, Masashi. Sponsor: Japan Science And Technology Corp

Request to Support a Strategic Planning Workshop for the Organization of Biological Field Stations to be held in October 2003, Bodega Marine Laboratory
Nagy, Eric S. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The Organization of Biological Field Stations (OBFS) has received support for a workshop for to develop a strategic plan for the organization. The current national scientific, political and financial ...

Research Experiences for Undergraduates at Mountain Lake Biological Station
Nagy, Eric S. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The Research Experiences for Undergraduates (REU) Site at Mountain Lake Biological Station (MLBS, University of Virginia) offers ten students a summer opportunity to conduct independent, self-motivated, ...

Research Experiences for Undergraduates at Mountain Lake Biological Station
Nagy, Eric S. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The Mountain Lake Biological Station (MLBS) was founded in 1929 as a teaching and research facility of the Biology Department of the University of Virginia. It is located on a mountain top in the Allegheny ...

REU For Undergraduates at Mountain Lake Biological Station
Nagy, Eric S. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The Mountain Lake Biological Station (MLBS) was founded in 1929 as a teaching and research facility of the Biology Department of the University of Virginia. It is located on a mountain top in the Allegheny ...

Role Of Sensory Feedback In Intersemental Coordination
Friesen, Wolfgang O (Otto). Sponsor: U.S. Nsf - Directorate For Biological Sciences
The proposed research is designed to increase our understanding of functionally complete neuronal oscillator systems. Specifically, we will investigate the role of sensory input in shaping the output ...

Separating Stochastic Events from Adaptive Evolution During a Biological Invasion: Keller
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Invasive species are a worldwide problem, and evolutionary processes are likely to be critical to their success. A fundamental question requiring an evolutionary approach is how the process of invasion ...

Sex Chromosome Evolution with Haploid Sex Determination
Hood, Michael E. Sponsor: U.S. National Science Foundation
An analogy is often drawn between sex (or mating-type) chromosomes in haploid-mating organisms, such as fungi, and the sex chromosomes in the majority of plants and animals. However, the mechanisms ...

Sex Ratio Evolution in Ephemeral Demes of a Gynodioecious Plant
Taylor, Douglas R. Sponsor: U.S. National Science Foundation
Gynodioecy is a condition in plant populations in which hermaphroditic and female individuals coexist. It arises when a mutation (called a cytoplasmic male sterility (CMS) factor) causes hermaphrodites ...

Sex Steroid Activation of Opioid Circuits in the CNS
Rissman, Emilie F. Sponsor: University Of California at Los Angeles
Influences of gonadal steroids on opioid receptors are of substantial basic science and clinical importance. Opioid receptors regulate CNS circuits controlling such diverse functions as analgesia and ...

Signaling from Beta-Amyloid Through Tau in Alzheimer's Disease
Bloom, George S. Sponsor: Alzheimer's Disease Association
Alzheimer's disease is ultimately a cell biological disorder. It directs destruction of a specific brain cell type, the neuron, and leaves uharmed the glial cells that account for –90% of the cells ...

Sleeping Sickness/Cytokine Effects on Biological Clock
Block, Gene D. Sponsor: U.S. National Heart, Lung, And Blood Institute
Our laboratory has developed expertise of the sleeping sickness model in rats. Dr Jama Mhlanga, from Bulawayo University in Zimbabwe, is now working with trypanosomes in Stockholm as a guest researcher ...

Society for Research on Biological Rhythms Meeting
Green, Carla B. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
The major objective of the Society for Research on Biological Rhythms (SRBR) Conference is to explore topics relating to the regulation and function of the circadian system. Because this meeting covers ...

Spatial Dynamics & Fluctuations at Population Margins
Newman, Timothy J. Sponsor: U.S. Nsf - Directorate For Biological Sciences
There has been an increasing interest in incorporating explicit spatial structure into ecological models. This research will investigate the effect of spatial structure on the dynamics of populations ...

Structural Determinants of Catalysis and Allosteric Regulation in DAHP Synthase
Bauerle, Ronald H. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Structure-fonction studies of three related enzyme systems have been carried out. Two are feedback-regulated enzymes from aromatic biosynthesis in bacteria, namely DA1IP synthase from the common pathway ...

Synaptic Mechanisms for Temporal Information Processing
Kawasaki, Masashi. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The results from the proposed activity will contribute to understanding fundamental mechanisms for temporal processing by the brain and will have implications not only for electrosensory and the auditory ...

Temporal & Spatial Gene Expression In Tobacco
Timko, Michael P. Sponsor: Philip Morris
The biosynthesis of alkaloids in most higher plants including tobacco is a developmentally activated process involving differential gene expression in specific tissues and cell types. Previous studies ...

Temporal Biology Training Program
Block, Gene D. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

Temporal Biology Training Program
Block, Gene D. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Timing plays a critical rote in biology. From precisely sequenced "once-in-a-lifetime" developmental events to neural, endocrine and motor osciliations, biological systems have evolved a capacity to internally ...

Temporal Biology Training Program
Block, Gene D. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Timing plays a critical rote in biology. From precisely sequenced "once-in-a-lifetime" developmental events to neural, endocrine and motor oscillations, biological systems have evolved a capacity to ...

Temporal Biology Training Program
Block, Gene D. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Timing plays a critical rote in biology. From precisely sequenced "once-in-a-lifetime" developmental events to neural, endocrine and motor oscillations, biological systems have evolved a capacity to ...

Temporal Biology Training Program
Green, Carla B. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

The Assembly of Characterization of Tau Oligomers
King, Michelle E. Sponsor: U.S. National Institute On Aging
Tau filaments are the primary component of the intracellular pathology found in Alzheimer's Disease, (and a large number of other related neurodegenerative diseases). In vitro models for studying ...

The Biomechanics of Morphogenesis in the Frog
Davidson, Lance A. Sponsor: U.S. Nih Of Child Health & Human Development

The Consequence of Early Selection on Life History Evolution
Roach, Deborah A. Sponsor: U.S. Nsf - Directorate For Biological Sciences
The effect of selection in natural populations depends on a combination of additive genetic variance for the trait, the developmental and temporal context in which the phenotype is expressed, and on ...

The Consequences of Sexual Conflict
Roach, Deborah A. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Scientists have long recognized that reproduction is costly to females. Research in various species finds that sexually active females have shorter lives than virgin females. Recent studies, in fruit ...

The Cowpea Genomics Project: Integrating Genespace Sequencing, Comparative Genomics & Molecular Marker Development
Timko, Michael P. Sponsor: Kirkhouse Trust
Modem molecular-based technologies, such as marker-assisted selection (MAS) in combination with conventional breeding strategies, have been successfully used for the genetic enhancement of other crop ...

The Determinants of Extreme Longevity in a Plant Species
Roach, Deborah A. Sponsor: Duke University
Senescence is defined demographically as an increase in mortality after reproductive maturity. Our current understanding of mortality patterns may be limited by the fact that most studies have been ...

The Effects of Sex-Differential Parasitism
Antonovics, Janis. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Differential effects of parasitism on males and females have been noted in a wide range of species, especially with regard to contrasting levels of disease prevalence and expression between the two ...

The Evolution of Molecular Parasites
Hood, Michael E. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Autonomously replicating DNA parasites, namely transposable elements, present a unique situation in evolutionary genetics: they not only reside within, but also constitute part of the heritable genetic ...

The Evolutionary Genetics of Invasiveness in Silene latifolia
Taylor, Douglas R. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Invasive species are one of the most important threats to natural ecosystems. A central issue in the study of biological invasions is to understand why species that are relatively benign in their native ...

The Influence of Disease on Seasonal Variation in Amphibian Life History Traits
Wilbur, Henry M. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Infectious diseases are poorly understood as selective forces on life history. Since the threat of disease is often heterogeneous in the environment, one would expect variation in traits that minimize ...

The Involvement of Tyramine in Cocaine Sensitization
Hirsh, Jay. Sponsor: U.S. National Institute On Drug Abuse
Exposure to psychostimulants such as cocaine induces sterotypic, reflexive motor behaviors in vertebrate animal models of psychostimulant abuse, and in Drosophila melanogaster. Repeated doses ...

The Macroecology and Biodiversity of Geographic Ranges in Mammals
Gittleman, John L. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Different animals and plants are found in different places. Kangaroos and eucalyptus trees are characteristic of Australia, whereas giant pandas live only in China. One must travel far to see a close ...

The Maintenance of Genetic Variation for Phenotypic Plasticity
Galloway, Laura F. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Genetic variation in phenotypic plasticity, the ability of individuals to respond to the environment, allows individuals to respond to current and future environmental change. Theory predicts that ...

The Population Genomics of an Invasive Species in its Native & Introduced Ranges
Taylor, Douglas R. Sponsor: Vanderbilt University
Comparative studies of the population genetics of invasive plants in the introduced and native ranges could help to identify several general features of the invasion process, especially if studies ...

The Potential for Gene Flow and Introgression into a Locally-adapted Population of Lobelia cardinalis
Galloway, Laura F. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Populations frequently adapt to their local environment, and this adaptation may be diminished by the influx of genes from different, non-local populations of the same species. The movement of genes ...

The Role of Fibrillin & Early Xenopus Patterning and Morphogenisis
Keller, Raymond E (Ray). Sponsor: U.S. Nih Of Child Health & Human Development
The long term objective of this research is to determine the role of the extracellular matrix( molecule, fibrillin, in early vertebrate morphogenesis, using the frog, Xenopus loevis, as an experimental ...

To Test the Effect of Aventis Compounds to Alter Circadian Rhythmicity
Menaker, Michael. Sponsor: Aventis Pharmaceuticals Products Inc.
Aventis would like to establish a method to examine the acute effects of compounds with the potential to alter circadian rhythmicity on period promoter driven luciferase expression in vivo utilizing ...

Training Program in Developmental Biology
Keller, Raymond E (Ray). Sponsor: U.S. Nih Of Child Health & Human Development
The goals of the training program are to provide training for graduate students and postdocs in developmental biology. Despite a few problems, described below, the training program is off to a good start ...

Trajectories of Mortality & Reproduction in a Natural Population
Roach, Deborah A. Sponsor: Duke University
Our earlier work, within this Program Project, challenges long-held beliefs about the demography of aging. Our large scale experimental studies have shown that for five species, mortality decelerates ...

Trajectories of Mortality and Reproduction in a Natural Population
Roach, Deborah A. Sponsor: Duke University
Our current understanding of late mortality patterns may be limited by the experimental conditions under which they have been studied. This project is designed to expand our understanding about the ...

Transcription Factors Regulating NtPMT Gene Expression in Tobacco
Timko, Michael P. Sponsor: Philip Morris

Transcriptional Output Pathways of the Circadian Clock
Wijnen, Herman. Sponsor: U.S. National Institute Of General Medical Science

Using Manipulated Phenotypes to Evaluate the Contribution of Maternal Effects to Life History Evolution in an Herbaceous Plant
Galloway, Laura F. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Maternal effects, the influence of the maternal phenotype on offspring character expression, are ubiquitous and predicted to have substantial and sometimes counter-intuitive influences on trait evolution. ...

Using Manipulated Phenotypes to Evaluate the Contribution of Maternal Effects to Life History Evolution in an Herbaceous Plant
Galloway, Laura F. Sponsor: U.S. Nsf - Directorate For Biological Sciences
One of the primary goals of the main grant is to test the hypothesis that maternal flowering time determines the timing of offspring germination in the herbaceous plant Campanula americana. ...

Using Y-Chromosome Microsatellites in Silene Latifolia to Study the Origin and Spread of Agriculture in Europe
Taylor, Douglas R. Sponsor: Jeffress Memorial Trust
There were two objectives for this project. First, we proposed to develop microsatellite markers in Silene latifolia, a weed of agriculture. Second we proposed to use those markers to study ...

WRKY Transcription Factors as Tools to Improve Drought Responses
Rushton, Paul J. Sponsor: U.S. Department Of Agriculture

Faculty:
Adler, Paul N – William R Kenan, Jr Profship in Biology
Antonovics, Janis – Lewis and Clark Professor
Bauerle, Ronald H – Professor Emeritus
Bloom, George S – Professor
Brodie, Edmund Darrell – Professor and Director of Mt Lake Biological Station
Castrucci, Ana Maria de Lauro – Senior Scientist
Condron, Barry G – Associate Professor
Cronmiller, Claire R – Professor
Deppmann, Christopher – Assistant Professor
Doyle, Susan Elizabeth – Visiting Research Scientist
Fang, Xiaolan – Research Associate in Biology
Fisher, Marilyn – Research Scientist
Frankfurter, Anthony – Professor Emeritus
Friesen, Wolfgang O – Professor
Galloway, Laura F – Professor
Garrett, Reginald H – Professor
Goda, Tadahiro – Research Associate in Biology
Gowda, Bhavani S – Research Scientist
Grainger, Robert M – Professor
Green, Carla B – Visiting Scholar
Henriksen, Melissa Ann – Assistant Professor
Hirsh, Jay – Professor
Homyk, Theodore – Lecturer
Huang, Kan – Research Associate in Biology
Kawasaki, Masashi – Professor
Keller, Raymond E – Alumni Council Thomas Jefferson Professor of Biology
Keller, Stephen R – Visiting Research Associate
Kittlesen, David J – Lecturer
Kopeny, Mark T – Associate Professor
Kozminski, Keith G – Associate Professor
Kretsinger, Robert H – Professor
Kucenas, Sarah C – Assistant Professor
Lamka, Michele L – Research Assistant Professor
Lawler, Jennifer – Research Associate in Biology
Lebedev, Nikolai – Research Associate Professor
Li, Lei – Assistant Professor
Matsushita, Atsuko – Visiting Scholar
McGlothlin, Joel William – Research Associate in Biology
Mellon, Deforest – Professor
Menaker, Michael – Professor
Nakayama, Takuya – Research Scientist
Periasamy, Ammasi – Research Professor
Provencio, Ignacio – Associate Professor
Rajapakse, Rohan – Research Associate in Biology
Roach, Deborah A – Associate Professor
Rollag, Mark – Research Scientist
Sami, Furqan – Visiting Research Assistant
Schafer, Dorothy – Associate Professor
Sellix, Michael Timothy – Research Associate in Biology
Shook, David R – Research Scientist
Silva, Antonia Francisca – Research Associate in Biology
Skoglund, Paul M – Research Scientist
Spano, Anthony J – Research Associate in Biology
Sun, Yuansheng – Research Associate in Biology
Taylor, Douglas R – Professor and Chair
Timko, Michael P – Professor
Vondrasek, Joanna Riffe – Research Associate
Wijnen, Herman – Assistant Professor
Wilbur, Henry M – BFD Runk Professor of Botany
Wormington, W M – Associate Professor
Wu, Martin – Assistant Professor
Yang, Yong – Research Associate in Biology
Zhang, Hongbo – Research Scientist

Related News: