Projects By Department of Chemistry:
2-Methoxyestradiol-Induced Protein Phosphorylation in Human Jurkat Leukemia Cells
Bazemore Walker, Carthene R. Sponsor: Leukemia Research Foundation
A naturally occurring estrogen metabolite, 2-methoxyestradiol (2ME), has been shown to be a potent inhibitor of tumor cell growth and has a seemingly profound specificity for malignant cells. Leukemia ... A Microfabricated Device for the Transfer of Cells from a Swab to an Analytical Microchip
Landers, James P. Sponsor: Federal Bureau of Investigation (FBI) Academy
A Novel Mass Spectrometric Ion Source for Proteomics
Hunt, Donald F (Don). Sponsor: U.S. National Center For Research Resources
The overall goals of this research are: (1) to develop a novel high performance liquid chromatographyelectrospray/matrix-assisted laser desorption/ionization-mass spectrometry (HPLC-ESI/MALDI-MS) interface ... A Study of Phospholipid Vesicle Structure & Function by Field Cycling Nuclear Magnetic Resonance Relaxation Spectroscopy
Bryant, Robert G. Sponsor: Virginia Academy of Science
A Study of the Metabolism of Fluorofelbamate
Macdonald, Timothy L. Sponsor: Wallace Labs.
Adsorbate Photochemical Dynamics & Catalysis
Harrison, A I (Ian). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
This research project addresses the detailed dynamics of photoinduced reactions at well-characterized solid surfaces. Using angle resolved time-of-flight measurements, Professor Ian Harrison and his students ... Alkali Metal Promoted Adsorbate Photochemistry and Catalysis
Harrison, A I (Ian). Sponsor: U.S. National Science Foundation
Alkali-Metal Doped Nanotube Sorbents: New Materials of Destruction of Chemical Agents
Yates, John T Jr. Sponsor: U.S. Dod-Defense Threat Reduction Agency
Alkane C-H Bond Breaking at Catalytic Metal Surfaces
Harrison, A I (Ian). Sponsor: American Chemical Society
The initial C-H bond scission of alkanes on heterogeneous metal catalysts is the rate determining step in the reforming reactions responsible for the industrial supply of H2 and synthesis ... Allene Directed Asymmetric Synthesis
Marshall, James A. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
The focus of this research is the examination of the synthetic utility of chiral allenylmetallic reagents of tin, boron, titanium, chromium and palladium. Particular attention will be focused on SE' additions ... Allene Directed Asymmetric Synthesis
Marshall, James A. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
The focus of this research is the examination of the synthetic utility of chiral allenylmetallic reagents of tin, boron, titanium, chromium and palladium. Particular attention will be focused on SE' additions ... Alliance for Cellular Signaling
Hunt, Donald F (Don). Sponsor: University Of Texas S.W. Medical Center At Dallas
An Electorchemical Adenosine Sensor for in vivo Applications
Venton, Barbara Jill (Jill). Sponsor: U.S. Nih Biomedical Imaging & Bioengineering
Apparatus for Oxygen Determination
Demas, James N. Sponsor: Pelikan Technologies, Inc.
Application of Fourier Transform Mass Spectrometry in Proteomics
Hunt, Donald F (Don). Sponsor: MDS Proteomics, Inc.
AS-CHEM CCI Phase I: Center for Chemistry of the Universe
Pate, Brooks H. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
AS-CHEM Collaborative Research: Development of a Diode Lase Cavity-Ringdown Spectrometer for Shipboard Measurements of the Stable Isotopes on Oceanic Methane
Lehmann, Kevin K. Sponsor: U.S. Nsf - Directorate For Geosciences
AS-CHEM Material Transfer/Biological Testing Agreement
Chruma, Jason J. Sponsor: E. I. Dupont
Asymmetric Synthesis by New & Efficient Chiral Catalyst
Pu, Lin. Sponsor: American Chemical Society
Bioassay-directed Search For Natural Products
Hecht, Sidney M. Sponsor: GlaxoSmithkline Beecham Pharmaceuticals
Biophysical Dynamics
Bryant, Richard Glenn. Sponsor: U.S. National Institute Of General Medical Science
Biophysical Dynamics
Bryant, Robert G. Sponsor: U.S. National Institute Of General Medical Science
The broad aims of this work are to define the amplitudes and time scales of molecular motions that are crucial for biological function. These motions of interest include intramolecular side chain and ... Capillary Coatings for Protein Separations
Landers, James P. Sponsor: Pfizer Pharmaceutical Labs.
Carbohydrate Protein Recognition-Implications for Cancer Vaccine Design
Mcgarvey, Glenn J. Sponsor: Jeffress Memorial Trust
Carbon Nanotube Modifed Microelectrodes for Insect Neurotransmitter Detection
Venton, Barbara Jill (Jill). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Carborane-Stabilized Mixed-Valence Metallooligomers
Grimes, Russell N. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research by Russell N. Grimes, Chemistry Department, University of Virginia, on mixed-valence metallo-carboranes. ... Cell Separation and DNA Extraction on a Modular Microdevice
Ferrance, Jerome P. Sponsor: U.S. Department Of Justice
Current estimates suggest that the backlog of DNA evidence to be analyzed by the criminal justice system exceeds 600,000 cases. In order to reduce this backlog, the time- and labor-intensive procedures ... Chemical Access to Cancer Relevant Carbohydrates
Mcgarvey, Glenn J. Sponsor: U.S. National Institute Of General Medical Science
In the broadest sense, the objective of this proposed research is to apply the discipline of synthetic organic chemistry to the study of the structure and reactivity of biological carbohydrates, especially ... Chipped-Pulse Fourier Transform Microwave Spectroscopy
Pate, Brooks H. Sponsor: U.S. Nsf - Directorate For Engineering
This project combines experimental tools in gas and condensed phase physical chemistry to examine the interplay between intramolecular and intermolecular processes in fundamental chemical kinetics.... Chiral Nonlinear Optical Polymers Containing Transition
Pu, Lin. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)
Closing the Non-Equilibrium Gap Between Ultrahigh Vacuum Surface Science, Catalysis
Harrison, A I (Ian). Sponsor: American Chemical Society
Collaborative Arabidopsis 2010 Project: Genomics & Proteomics Approaches to Function of Tyrosine Phosphatases in Arabidopsis
Hunt, Donald F (Don). Sponsor: U.S. Nsf - Directorate For Biological Sciences
Reversible protein phosphorylation is the most common mechanism for cellular regulation in eukaryotic systems. Studies have demonstrated that serine/threonine phosphorylation plays a key role in the regulation ... Collaborative Research: Development of an Ultrabroad Bandwidth UV-Vis Cavity Enhanced Spectroscopy Spectrometer
Lehmann, Kevin K. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Collaborative Research: Development of Chirped-Pulse Fourier Transform Microwave Spectrometers for Applications in Biomolecule Electronic Spectroscopy
Pate, Brooks H. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Recent advances in the technology of test and measurement equipment driven by the computer and telecommunications industries have made possible the development of a new rapid scan, broadband, Fourier ... Combined Pressure & Electo-Elution of DNA for Forensic Analysts
Landers, James P. Sponsor: U.S. Department Of Justice
Computational Photonic Metamaterials & Non-Linear Ultra-Fast Optics
Kolasinski, Kurt W. Sponsor: Norfolk State University
Conduct of Studies on the Development of Microfluidic Devices for Rapid & Complete Protein Digestion
Landers, James P. Sponsor: Pfizer Pharmaceutical Labs.
Coordinated Studies of the Reaction Dynamics for Isolated and Solvated Molecules
Pate, Brooks H. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Brooks Pate of the University of Virginia will investigate the reaction dynamics of isolated molecules ... Coordinated Study of Isomerization Reactions in Isolated Molecules and Molecules in Solution
Pate, Brooks H. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Brooks Pate of the University of Virginia is supported by a grant from the Experimental Physical Chemistry Program to develop a new molecular beam spectrometer and to use it to study gas phase isomerization ... Design and Synthesis of Novel Sodium Channel Blockers Based on a Combined Phenytoin-Lidocaine
Brown, Milton L. Sponsor: Jeffress Memorial Trust
Inhibitors of neuronal voltage gated sodium channels have produced useful classes of clinical agents in the treatment of pain, seizures and arrhythmia. We have discovered a novel sodium channel blocker ... Design, Synthesis & Evaluation of Novel Phthalimide Mim
Brown, Milton L. Sponsor: Carilion Biomedical Institute
Detection of Amino Acids
Pu, Lin. Sponsor: U.S. Nasa - Goddard
Fluorescence-based molecular sensors are of great utility in substance analysis because of the high sensitivity of fluorescence and the easily available instrument. Fluorescence can also provide many ... Determination of Pharmacokinetic Profiles of Adenosine Analogs
Macdonald, Timothy L. Sponsor: Adenosine Therapeutics, LLC
Determining the Structure & Molecular Determinants of Membrane Protein
Columbus, Linda. Sponsor: Jeffress Memorial Trust
Development of a 2-D Microwave Spectrometer
Pate, Brooks H. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
With support from the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation and Facilities (CRIF) Programs, Prof. Brooks H. Pate of the University of Virginia will develop a ... Development of a Bili-Microchip-Analyzer. Shipboard Determination of PAYCO. on Ocean Water
Landers, James P. Sponsor: Wake Forest University
This ocean science technology development project will provide oceanographers with a shipboard instrument capable of separating and quantifying phycobiliproteins in seawater. No routine method currently ... Development of a Bili-Microchip-Analyzer: Shipboard Determination of Phycobiliproteins in Ocean Water Samples
Landers, James P. Sponsor: U.S. National Science Foundation
Contributions Within Discipline: Picoplankton, especially cyanobacteria, were originally thought to occur in low concentrations in the marine environnent because of the difficulty in sampling and identifying ... Development of a Lifetime Based Luminescense PH Sensing System
Demas, James N. Sponsor: Airak, Inc.
The Demas group will be working on microtiter plate wells pH and oxygen based sensors. In the case of oxygen sensors, one of the goals will be to improve the reproducibility of the chemistry. For the ... Development of a Quantitative PCR Assay for Total Human DNA & Male DNA
Landers, James P. Sponsor: Orchid Biosciences, Inc.
Development of an Electrochemical Adenosine Sensor
Venton, Barbara Jill (Jill). Sponsor: Jeffress Memorial Trust
Development of Asymmetric Rhenium Dearomatization Reagents
Harman, Walter D (Dean). Sponsor: American Chemical Society
Development of Novel Modulators of Angiogenesis
Brown, Milton L. Sponsor: Carilion Biomedical Institute
This project is aimed at the discovery, synthesis and evaluation of novel phthalimides as promoters of endothelial cell proliferation and as molecular targets of angiogenesis. This collaboration explicitly ... Development of Organocatalysts for the Asymmetric Alkyne
Pu, Lin. Sponsor: American Chemical Society
Diels-Alder Cycloaddition Reactions with Dihapto-Coordinated Pyridines
Harman, Walter D (Dean). Sponsor: American Chemical Society
DNA Quantification and PCR Amplification on a Modular Microdevice
Landers, James P. Sponsor: U.S. Department Of Justice
Forensic analysis of DNA for identification of individuals involved in crimes relies on determining the pattern of STR fragments from specific loci of the human genome. Because of the time required and ... DuPont Young Professor Grant
Fraser, Cassandra L. Sponsor: E. I. Dupont
Dynamics of Ions in Superfluid Helium Nanodroplets
Lehmann, Kevin K. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Elaboration of Modified Proteins Using Misacylated tRNA's
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
The long term goal of this work is the elaboration and study of proteins containing synthetic amino acids at specific, predetermined positions. These are to be incorporated by readthrough of nonsense ... Employing Solvophobic Effects Toward the Synthesis of Bioactive Biaryl & Diarylether Macrocycles
Chruma, Jason J. Sponsor: Jeffress Memorial Trust
The conformational constraint of peptide backbones through intramolecular cross-linkage is an attractive strategy for invoking unique, desirable, and potent biological activity from the effected peptide. ... Employing Solvophobic Effects Toward the Synthesis of Bioactive Biaryl and DiaryLether Macrocycles
Chruma, Jason J. Sponsor: Jeffress Memorial Trust
Enantioselective Fluorescent Sensors & Applications
Pu, Lin. Sponsor: U.S. Nih Biomedical Imaging & Bioengineering
Enantioselective Fluorescent Recognition of a-Hydroxycarboxylic Acid Using Chiral Sensors.
We have discovered that bisbinaphthyl-based macrocycle A and its enantiomer can carry out highly enantioselective ... Enantioselective Fluorescent Sensors and Applications
Pu, Lin. Sponsor: U.S. National Institute Of General Medical Science
Enantioselective Fluorescent Recognition of a-Hydroxycarboxylic Acid Using Chiral Sensors.
We have discovered that bisbinaphthyl-based macrocycle A and its enantiomer can carry out highly enantioselective ... Evaluation of Solid Phases for Microchip DNA Extraction and Purification
Landers, James P. Sponsor: Canon U.S. Life Sciences, Inc.
Fellowship on Behalf of P.J. Griffith
Brown, Milton L. Sponsor: United Negro College Fund
Fiber Optic Affinity Ligand Sensors for Quantification of Petroleum & Bioremediation
Fraser, Cassandra L. Sponsor: Luna Innovations, Inc.
Functionalization of Aromatic Heterocycles
Harman, Walter D (Dean). Sponsor: U.S. National Institute Of General Medical Science
With the advent of high throughput screening procedures to identify potential new pharmaceuticals, there is a great demand for new synthetic methods that allow the rapid, atom efficient, stereospecific ... Gamma-Hydroxy-Alpha, Beta-Acetylenic Esters
Pu, Lin. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
High-power Microwave-infrared Double-resonance
Pate, Brooks H. Sponsor: Jeffress Memorial Trust
IGERT: Science & Engineering of Laser Interactions with Matter
Harrison, A I (Ian). Sponsor: U.S. Nsf - Directorate For Ed. & Human Resources
This Integrative Graduate Education and Research Training (IGERT) award supports the establishment of an multidisciplinary, multi-institution graduate training program of education and research in the ... Implementation Of Microwave Cavity Methods
Pate, Brooks H. Sponsor: Dreyfus Foundation
Incorporation of unnatural Amino Acids into Protein Cha
Hecht, Sidney M. Sponsor: Annovis, Inc.
Inhibitors of P90 Rsk
Hecht, Sidney M. Sponsor: National Foundation for Cancer Research
The long term goals of this work include the development of an understanding of the role(s) of the ser/thr protein kinase Rsk family in signal transduction within the mitogen-activated protein kinase ... Inhibitors of p90Rsk
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
Integrated Microanalytical Technologies for Genomic Ana
Landers, James P. Sponsor: Agilent Technologies, Inc.
Integrated Sample Preparation for Genomic Analysis in Micro Device Format
Landers, James P. Sponsor: Georgia Institute Of Technology
In the first year, a second generation µ-EAS (Frazier, U. of Utah) will be designed and fabricated for cell sorting and selection. The µ-EAS will be designed for highly parallel and serial cellular analysis. ... Interaction of Bleomycin with RNA and DNA
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
1. Description of Studies Conducted During the Past Reporting Period A. Transfer RNAs as Therapeutic Targets for BLM
We have demonstrated that tRNAPh' and tRNALYs3 are the two mammalian tRNAs that ... Interactions Between Nanoparticles in Supercritical Fluids
Egorov, Sergei. Sponsor: Jeffress Memorial Trust
Synthetic preparation of nanocrystals using controlled precipitation techniques typically involves dissolution of metallic or semiconductor nanocrystals, which are coated with chemically adsorbed passivating ... Interactive Software Across the Science Curriculum with Java & XML
Grisham, Charles M. Sponsor: U.S. Nsf - Directorate For Ed. & Human Resources
Using Java/XML software, suites of design tool/player pairs of programs and educational materials for the chemistry and biochemistry curriculum are being developed. The design tool software permit instructors ... Investigations into the Interaction of Metal Atoms with Hydrogen: Infrared Spectra of Novel Metal Hydride Species in Solid Hydrogen
Andrews, Lester S (Lester). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
In this award, supported by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Lester Andrews of the University of Virginia will conduct research to study the infrared absorption ... Investigations into the Laser Ablation Process and the Pursuit of New Chemical Applications
Andrews, Lester S (Lester). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Lester Andrews of the University of Virginia is supported by a grant from the Experimental Physical Chemistry Program to continue his spectroscopic studies of laser ablation to obtain absorption spectra ... Isolation of Focal Adhesion Kinase-Specific Modulators
Hecht, Sidney M. Sponsor: Luna Innovations, Inc.
Jayson Rieger Fellowship
Macdonald, Timothy L. Sponsor: American Chemical Society
Laboratory Tests of CP-FTMW Detection of Gas Mixtures using Molecular Beam Sample Detection
Pate, Brooks H. Sponsor: Science Applications Intrnl Corp
Light Emitting Polymeric Metal Complexes
Fraser, Cassandra L. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
LPG-Based Optical Fiber Fluorescent Sensor for Detection of Biological and Chemical Agents
Landers, James P. Sponsor: Luna Innovations, Inc.
Lysophosphatide Acid & the Progression of Prostate Cancer
Macdonald, Timothy L. Sponsor: U.S. National Cancer Institute
Lysophosphatidic Acid Antagonism in Ovarian Cancer Therapy
Macdonald, Timothy L. Sponsor: Carilion Biomedical Institute
This proposal represents the continuation of a 2003 FEST grant with the same project title. It proposes to exploit the established sensitivity of ovarian cancer to lysophosphatidic (LPA) through blockade ... Magnetic Relaxation Control
Bryant, Richard Glenn. Sponsor: U.S. National Institute Of General Medical Science
Magnetic Relaxation Dispersion
Bryant, Robert G. Sponsor: U.S. Nih Biomedical Imaging & Bioengineering
The magnetic field dependence of the nuclear spin-lattice relaxation rate constant provides the Magnetic Relaxation Dispersion profile (MRD). The MRD contains most of the dynamical information that ... Magnetic Relaxation dispersion
Bryant, Robert G. Sponsor: U.S. Nih Biomedical Imaging & Bioengineering
Matrix Spectroscopic & Computational Investigations of Agostic Bonding
Andrews, Lester S (Lester). Sponsor: American Chemical Society
Measurement of Lumigan & 17-Phenyl-18,19,20-Trinor-PGF2a, in Human Aqueous Humor
Macdonald, Timothy L. Sponsor: Finnegan, Henderson, Farabow Garrett & Dunner, LLP
Mechanism & Inhibition of Human DNA Topoisomerase I
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
Mechanism of Phospholipase C-Gammal Activation
Jones, Gwenith A. Sponsor: U.S. Nsf - Directorate For Biological Sciences
Proteins of diverse function and structural features often can be grouped together because they share common methods for controlling function. Such is the case for some proteins involved in signal transduction. ... Mechanisms of Adenosine Formation During Ischemia
Venton, Barbara Jill (Jill). Sponsor: American Heart Association - Mid-Atlantic Affiliat
Membrane Interactions of C2 Domains
Cafiso, David S. Sponsor: U.S. National Institute Of General Medical Science
Metal Ions In Dna Triplexes
Sabat, Michal. Sponsor: NATO
Micro-Solid Phase Extraction of DNA on Microchips
Landers, James P. Sponsor: U.S. National Human Genome Research Institute
Despite the current fad that the 'post-genome' era is coming to an end, it is likely that genetic analysis will continue to be a prolific field of exploration. Genetic analytical methods will be critical ... Microdevice for DNA Purification
Landers, James P. Sponsor: U.S. National Cancer Institute
With an ever-increasing interest in the molecular typing of cells from histologic tissue sections, the ability rapidly and efficiently extract DNA from the selected cells will be of paramount importance. ... Microfluidic Devices to Profile and Derivatize Lipids
Landers, James P. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Microfluidic Technology for Drug Stability/Pharmacotherapeutics
Landers, James P. Sponsor: Universities Space Research Association
Mimics of Helix Turn Helix Peptides
Etzkorn, Felicia A. Sponsor: U.S. National Institute Of General Medical Science
Mimics of Helix Turn Helix Peptides
Macdonald, Timothy L. Sponsor: U.S. National Institutes Of Health
Molecular Basis for C2 Domain-Membrane Interactions
Cafiso, David S. Sponsor: U.S. National Institute Of General Medical Science
Molecular Interactions Regulating Cell Signaling
Cafiso, David S. Sponsor: U.S. Nsf - Directorate For Biological Sciences
A number of proteins that are involved in cell signaling pathways are water-soluble but participate in signaling only when they are associated with the membrane interface. One objective of this project ... Molecular Mechanisms of Membrane Transport
Cafiso, David S. Sponsor: U.S. National Institute Of General Medical Science
Active membrane transport is a critical process for normal cell metabolism, including the maintainence of iongradients, osmotic balance, action potentials and apoptosis. The proposed work will focus on ... Nanoactive Metal Oxides
Yates, John T Jr. Sponsor: NanoScale Materials, Inc.
Natural Products Discovery - Nuclear & Signaling Targets
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
The current specific aims are as follows:
1. To access natural product extracts from the NCI Repository and from collections at the University of Virginia.
1. To discover new bioactive natural products ... Natural Products Discovery - Nuclear & Signaling Targets
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
The long term objective of this NCDDG is the identification of compounds suitable for development as antitumor agents. This is to be done by 1) utilizing existing, validated assays to guide the screening/isolation ... Non-Contact Microchip PCR Based on Infrared Heating
Landers, James P. Sponsor: U.S. National Human Genome Research Institute
Despite the current fad that the `genome era' is coming to an end (as the 'post-genome era' gets underway), genetic analysis will undoubtedly continue to be a prolific field of exploration. Genetic analytical ... Noncontact Infrared-Mediated Theromcycling for Chip-PCR
Landers, James P. Sponsor: U.S. National Human Genome Research Institute
Novel Tools for the Study of HIV-1 RNase H Inhibition
Hecht, Sidney M. Sponsor: U.S. Nih Allergy & Infectious Diseases
Reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is a multifunctional enzyme that serves as major target for the development of drugs to treat infection with this virus. Both ... On-Chip DNA Purification/PCR for Cancer Diagnostics
Landers, James P. Sponsor: U.S. National Cancer Institute
Optical Fiber Based Sensor for In-Situ Measurement of Moisture Within
Fraser, Cassandra L. Sponsor: Luna Innovations, Inc.
Organic Transformations of ETA-2-Arene Complexes
Harman, Walter D (Dean). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Organic Transformations with Dihapto-Coordinated Arene Complexes
Harman, Walter D (Dean). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Organic Transformations with h2-Arene Complexes of Rhenium
Harman, Walter D (Dean). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
With the support of the Organic and Macromolecular Chemistry Program, Professor W. Dean Harman, of the Department of Chemistry at the University of Virginia, is studying organic transformations using ... PECASE: Metal Core Macromolecules with Tunable Properties
Fraser, Cassandra L. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Dr. Cassandra L. Fraser, Chemistry Department, University of Virginia, is supported by a Faculty Early Career Development (CAREER) award from the Inorganic, Bioinorganic and Organometallic Chemistry Program. ... Photochemistry and Photophysics of Transition Metal Complexes
Demas, James N. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program provides continued support to Dr. James N. Demas of the Chemistry Department, University of Virginia, for research on use ... Photon & Electron Stimulated Chemistry of Adsorbates
Harrison, A I (Ian). Sponsor: U.S. Department Of Energy - Chicago
This fundamental research program will employ non-thermal electron transfer chemistry to quantitatively investigate the nature of the transition states of some important catalytic dissociative adsorption ... Photophysics & Photochemistry of Surpramolecular Metal Complexes for Photodynamic Therapy
Demas, James N. Sponsor: Carilion Biomedical Institute
Photophysics & Photochemistry of Transition Metal Complexes with Applications to Sensors
Demas, James N. Sponsor: U.S. National Science Foundation
The Inorganic, Bioinorganic and Organometallic Chemistry Program of the Division of Chemistry, National Science Foundation, supports the work of Dr. James N. Demas of the Department of Chemistry, University ... Photophysics & Photochemistry of Transition Metal Complexes with Applications to Sensors
Demas, James N. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Luminescent complexes of Ru(II), Os(II), Re(I), and Ir(III) with a-diimine ligands are currently revolutionizing sensor technology. However, rapid advances and the ability to commercialize these systems ... Phthalimide Promoters of Endothelial Cell Proliferation: Molecular Targets of Aortic Angiogenesis
Brown, Milton L. Sponsor: Carilion Biomedical Institute
Polymeric Metal Complexes as Multifunctional Molecular Probes
Fraser, Cassandra L. Sponsor: U.S. Nsf - Directorate For Engineering
Polymeric metal complexes (PMCs) are a new class of multifunctional biomaterials that combine detection, protection, targeting, triggered release and degradation functions in imaging agents and drug delivery ... Polymerization of Propylene Using Group IV Catalysts Based on Monomeric Polymeric Binaphthyls
Pu, Lin. Sponsor: BP Amoco Polymers, Inc.
Probing HIV RT Structure & Function via Introduction of Unnatural Amino Acids
Hecht, Sidney M. Sponsor: SAIC-Frederick, Inc.
While a limited number of aminoacylated dinucleotides (a key element in this process) are commercially available, progress in this area will require chemical synthesis of additional derivatives and efficient ... Processed Antigen Characterization by Mass Spectrometry
Hunt, Donald F (Don). Sponsor: U.S. Nih Allergy & Infectious Diseases
Identification of disease associated antigens is an often an important step in the development of vaccines or other immune system modulators that are effective against bacterial and viral infections, ... Program Income Magnetic Relaxation Dispersion
Bryant, Robert G. Sponsor: U.S. Nih Biomedical Imaging & Bioengineering
Proposed Synthesis of Dictyostatin-1
Marshall, James A. Sponsor: Eli Lilly
Proposed Synthesis of Dictyostatin-1
Marshall, James A. Sponsor: Eli Lilly
Protein Sequencing by Tandem Mass Spectrometry
Hunt, Donald F (Don). Sponsor: U.S. National Institute Of General Medical Science
Protein Sequencing by Tandem Mass Spectrometry
Hunt, Donald F (Don). Sponsor: U.S. National Institute Of General Medical Science
Overall goals of the proposed research are two in number: (1) to continue the development of mass spectrometry instrumentation, software, and methodology for the identification and sequence analysis of ... Protein-Phosphoinositide Binding Related to Exocytosis
Cafiso, David S. Sponsor: U.S. National Institute Of General Medical Science
Purchase of Bruker Pulse EPT Spectrometer
Cafiso, David S. Sponsor: U.S. National Center For Research Resources
Funds are requested to purchase a Bruker Elexsys 580 EPR spectrometer. This is a highly versatile commercial EPR machine that will be capable of both CW operation as well as a broad range of pulse experiments ... Research Experience for Undergraduates
Demas, James N. Sponsor: U.S. National Science Foundation
During the summers of 2007-09, an intensive 10-week research
program for undergraduates will be sponsored with the key goals of introducing meaningful research, enhancing political and ethical responsibility, ... Research Experiences for Undergraduates in Chemistry at UVA
Demas, James N. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
This Chemistry Division award supports a Research Experiences for Undergraduates (REU) site at the University of Virginia, where a previous REU site was funded for 1997-1999. James Demas is the site's ... Research Fellowship For Glenn Foulds
Etzkorn, Felicia A. Sponsor: Fdn. For Res. Science & Technology
Separation and Four Color Detection of Amplified Products by Electrophoresis
Landers, James P. Sponsor: U.S. Department Of Justice
Separation of Sperm and Epithelial Cells on a Microfluidic Device
Landers, James P. Sponsor: U.S. Department Of Justice
Site Isolated Polymeric Metal Complexes: From Modular Synthesis to Responsive Nanoscale Assemblies
Fraser, Cassandra L. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Cassandra L. Fraser at the University of Virginia to prepare and study polymeric metal complexes ... Sloan Research Fellowship
Fraser, Cassandra L. Sponsor: Sloan Foundation
Sodium Channel Blockers as Inhibitors of Prostate Cancer
Brown, Milton L. Sponsor: U.S. National Cancer Institute
Metastatic prostate adenocarcinoma (PCa) is the second most common cause of cancer-related deaths among men in North America. Recently, the invasive and metastatic potential of prostate cancer tells has ... Structure & Mechanism of Adenylyl Cyclase Toxin
Grisham, Charles M. Sponsor: Jeffress Memorial Trust
Structure and dynamics of bacterial membrane protein - receptor interactions
Columbus, Linda. Sponsor: U.S. National Institute Of General Medical Science
Studies in S1P Chemical Biology
Macdonald, Timothy L. Sponsor: Biogen
Study of Main Chain Chiral Conjugated Polymers
Pu, Lin. Sponsor: U.S. Dod - Navy - Office Of Naval Research (Onr)
Supercritical Fluids: Tunable Media for Chemical Reactions and Materials Processing
Egorov, Sergei. Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Sergei Egorov, at the University of Virginia, is supported by the Theoretical and Computational Chemistry Program to pursue research in supercritical fluids and their uses as a tunable media for chemical ... Surface Bonding of Molecules, Their Reactions & Confinement Effects in the Chemisorbed Layer
Yates, John T Jr. Sponsor: U.S. Department Of Energy - Chicago
Surface Science Engr. & Medicine Seminar Series
Harrison, A I (Ian). Sponsor: Gwathmey Trust
Synthesis of Annonaceous Acetogenins & Analogues
Marshall, James A. Sponsor: U.S. National Institute Of General Medical Science
The total synthesis of various Annonaceous acetogenins will be undertaken. The targeted compounds exhibit high levels of growth inhibition against various human tumor cell Unes but they are generally ... Synthesis of Annonaceous Acetogenins & Analogues
Marshall, James A. Sponsor: U.S. National Institute Of General Medical Science
The total synthesis of various Annonaceous acetogenins will be undertaken. The targeted compounds exhibit high levels of growth inhibition against various human tumor cell Unes but they are generally ... Synthesis of Bleomycin Group Antibiotics & Analogues
Hecht, Sidney M. Sponsor: U.S. National Cancer Institute
The antitumor agent bleomycin is used clinically, both as a single agent and in combination chemotherapy for the treatment of several types of cancer. For example, bleomycin is efficacious against squamous ... Synthesis of Luciferase Analogues Emitting at Longer Wavelength
Hecht, Sidney M. Sponsor: Xenogen Corp.
The chemical basis of the production of visible light by firefly luciferase has been studied intensively for more than 30 years, resulting in general agreement about the nature of the excited state oxyluciferin ... Synthesis of Metal Core Polyoxazolines
Fraser, Cassandra L. Sponsor: Jeffress Memorial Trust
Synthesis of Novel Tubulin Depolymerizers
Brown, Milton L. Sponsor: OcuCure Therapeutics, Inc.
Synthesis of Tumor Inhibitory Compunds
Marshall, James A. Sponsor: U.S. National Institute Of General Medical Science
Synthesis of Tumor Inhibitory Compunds
Marshall, James A. Sponsor: U.S. National Institute Of General Medical Science
Synthesis of Tumor Inhibitory Marine Natural Products
Marshall, James A. Sponsor: U.S. National Cancer Institute
The total synthesis of a number of marine natural products in the polyketide and diterpene families will be undertaken. The targeted compounds exhibit high levels of growth inhibition against various ... Synthesis of Tumor Inhibitory Marine Natural Products
Marshall, James A. Sponsor: U.S. National Cancer Institute
The total synthesis of a number of marine natural products in the polyketide and diterpene families will be undertaken. The targeted compounds exhibit high levels of growth inhibition against various ... Synthetic Approaches to Metal-Centered Block Copolymers
Fraser, Cassandra L. Sponsor: American Chemical Society
Theoretical Calculations of Polynuclear Transition Meta
Andrews, Lester S (Lester). Sponsor: U.S. Nasa - Ames
Thermo-Optical Detection with Interferometric Microchips
Landers, James P. Sponsor: Luna Innovations, Inc.
Conventional clinical analyses utilize slab gel and capillary electrophoresis (CE) to separate and detect components of interest, most notably proteins and DNA. Recently, miniaturized CE methods,' using ... Towards Energy Sustainability
Harrison, A I (Ian). Sponsor: U.S. Nsf - Directorate Math. & Physical Sciences
Ultra-Broad Bandwidth Cavity Enhanced Spectroscopy with Application to Study of Combustion
Lehmann, Kevin K. Sponsor: American Chemical Society
UVA Institute for Proteomic Research
Hunt, Donald F (Don). Sponsor: Novartis
Virtual Biochemistry - An Interactive 3D Laboratory Course Using Java
Grisham, Charles M. Sponsor: U.S. Nsf - Directorate For Ed. & Human Resources
The Virtual Biochemistry Laboratory is a comprehensive, fully interactive, three-dimensional laboratory course (on CD-ROM) in biological chemistry for college undergraduate students. This virtual laboratory ...
Faculty:
Allen, Ralph O – Dir of Environmental Health & Safety & Assoc VP, Professor
Andreatta, Jeremy Rex – Research Associate in Chemistry
Andrews, Lester S – Professor Emeritus
Ankney, Margaret T – Research Scientist
Ballard, Thomas E – Research Associate in Chemistry
Bare, William Douglas – Visiting Professor
Bienvenue, Joan M – Visiting Scholar
Bolano-Garcia, Tamara – Visiting Research Associate
Bryan, Robert F – Professor Emeritus
Bryant, Robert G – Professor
Buettner, Michael – Research Associate in Chemistry
Burland, Donald M – Research Scientist
Burnett, Robert E – Professor
Cafiso, David S – Commonwealth Prof of Chemistry & Prof and Chair of Chemistry
Chordia, Mahendra D – Research Scientist
Chruma, Jason J – Assistant Professor
Columbus, Linda – Assistant Professor
Coult, Natalie – Research Assistant
Coyne, Erika Derro – Visiting Scholar
Demas, James N – Professor
Diakova, Galina B – Research Scientist
Egorov, Sergei – Associate Professor
Fang, Huaifang – Research Associate in Chemistry
Ferrance, Jerome P – Research Assistant Professor
Fraser, Cassandra L – Professor
Friberg, Stig E – Research Scientist
Gerrans, Graeme C – Professor
Geysen, Hendrik M – Professor
Grimes, Russell N – Professor Emeritus
Grisham, Charles M – Professor
Gunnoe, Thomas Brent – Professor
Harman, Walter D – Professor
Harrison, A I – Professor
Hecht, Sidney M – Professor Emeritus
Herrick, Dawn Zbell – Research Associate in Chemistry
Hunt, Donald F – University Professor
Jambunathan, Kalyani – Research Associate in Chemistry
James, Patrick Francis – Research Associate in Chemistry
Jeffery, Erin D – Senior Scientist
Kersey, Farrell Ray – Research Associate in Chemistry
Lai, Liqi – Research Associate in Chemistry
Landers, James P – Professor
Lara Vargas, Francisco Jesus – Visiting Research Scientist
Lehmann, Kevin K – William R. Kenan,Jr.,Professor of Chemisry
Macdonald, Timothy L – Professor
Maitra, Sushmit – Research Associate in Chemistry
Marshall, James A – Professor
Mcgarvey, Glenn J – Associate Professor
Metcalf, David H – Lecturer
Mokdad, Audrey – Research Associate in Chemistry
Mura, Cameron – Assistant Professor
Neurock, Matthew – Professor
Pate, Brooks H – William R Kenan, Jr Profship in Chemistry
Phaneuf, Christopher – Visiting Scholar
Pouy, Mark J – Research Associate in Chemistry
Price, Carol Webber – Research Associate in Chemistry
Pu, Lin – Professor
Quillian, Brandon Pevel – Research Associate in Chemistry
Rajappan, Mahesh – Research Associate in Chemistry
Raut, Ujjwal – Research Associate in Chemistry
Richardson, Frederick S – Professor Emeritus
Sabat, Michal – Senior Scientist
Shabanowitz, Jeffrey – Principal Scientist
Shultis, David D – Research Associate in Chemistry
Sundberg, Richard J – Professor of Chemistry
Tang, Yongxin – Research Associate in Chemistry
Tikhonov, George Yuryevich – Research Associate in Chemistry
Trindle, Carl O – Professor
Udeshi, Namrata D – Research Associate in Chemistry
Venton, Barbara Jill – Assistant Professor
Wang, Xuefeng – Research Scientist
Xu, Yida – Research Associate in Chemistry
Yates, John T – Professor of Chemistry
Zhang, Zhen – Research Associate in Chemistry
Zhou, Li-Hong – Visiting Research Assistant
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