Department of Biochemistry and Molecular Genetics |
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Biochemistry is the study of the chemical processes and transformations in living organisms. Molecular genetics is the field of biology which studies the structure and function of genes at a molecular level. We recently changed the name of our department and graduate program to biochemistry and molecular genetics to reflect the increasing use of genetics, molecular biology and computational biology in identifying and characterizing the structure and activities of important cellular constituents. The faculty consists of geneticists, biochemists, molecular biologists and biophysicists, whose research focuses on computational biology, DNA replication, transcriptional regulation, chromatin folding, cell cycle traverse, genetic instability, nuclear import, structure of membranes and nucleoprotein complexes, extracellular matrix formation, protease function, and antibody selectivity and design. Thus, the department represents a broad range of research interests with special emphasis on biochemistry of the nucleus. Contact: PO Box 800733 Charlottesville, VA 22908-0733 Phone: 434-924-2508 Fax: 434-924-5069 Website: http://www.virginia.edu/bmg |
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projects | faculty | news |
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Projects By Department of Biochemistry and Molecular Genetics: A Novel Coregulator of Androgen Receptor & Its Role in Prostate Cancer A Novel Coregulator of Estrogen Receptor & Potential Tumor Suppressor A Novel Corepressor of Estrogen Receptor A Novel Corepressor of Estrogen Receptor Acquisition of 200kev FEG Cryo-Electron Microscope Amplification: A Model for Genetic Instability in Cancer Analysis of Cdc20-Mad2 in Spindle Checkpoint Signalling Analysis of Histone Acetyltransferase/Transcriptional A Analysis of rDNA Chromatin in Aging Yeast Cells Analysis of rDNA Chromatin in Aging Yeast Cells Analysis of the Relationship Between COBRA1, BRCA1 and ERalpha in Transcriptional Regulation Antiapoptotic Mechanisms in Prostate Cancer Antiapoptotic Role of NF-kB in Calcium Signaling Antigen Based Heteropolymers Brca1 Function In Chromatin Remodeling & Regulation BRCA1 Function in Epithelial-Stromal Interactions During Breast Cancer Development BRCA1 Function in Gene Regulation & Tumor Suppression BRCA1 in Gene Regulation & Tumor Suppression Calorie Restriction-Mediated Life Space Extension in Yeast Calorie Restriction-Mediated Life Space Extension in Yeast Cell Cycle Regulatory Mechanisms of Aurora/IP11 Kinases Characterization of a Novel Histone H3 Phosphorylation Mark in DNA Replication Chromatin Remodeling and Programmed DNA Elimination Chromatin Remodeling Function Of Brca1 Chromosomal Protein Function & Phosphorylation Clearance of Pathogens CLL Topics, Inc. R. Taylor Project Comparison of HuMax CD20 & Rituximab With Respect to Real Time CDC & C3b Deposition Comparison of Protein Sequences & Structures Comparison of Protein Sequences & Structures Control of Sir2 by Nuclear NAD Salvage Pathways Control of Sir2 by Nuclear NAD Salvage Pathways Cooperation Between BRCA1 & JunB in Gene Regulation & Tumor Suppression Copine-I: Modulator of NF-kappa B Transcription and Prostate Cancer Survival Coupling Signaling to Chromatin Modifications Development of a Mouse with Inducible Estrogen Receptor Alpha Function Dissection of the Inner Centromere Regulatory Network DNA Replication DNA Replication DNA Replication Dynamics of the Vertebrate Kinetochore Effects of Chromatin Architecture on Origin Activity Energetic Regulation of Puberty Enzymology & Biological Func of Histone Acetylation Enzymology and Functioins of Histone Phosphorylation Epigenetics, Hormones & Sex Differences in Autism Incidence Fellowship on behalf of Adam Mueller; O-GlcNAc Misregulation and Aneuploidy in Breast Cancer Progression Fellowship on behalf of Adam Mueller; O-GlcNAc Misregulation and Aneuploidy in Breast Cancer Progression Fellowship on behalf of Adam Mueller; O-GlcNAc Misregulation and Aneuploidy in Breast Cancer Progression Fellowship on Behalf of Jin Ho Park Fellowship on Behalf of K. Terai Fellowship on behalf of Kimberly R. Wiggins: Characterization of CHD Family Chromodomains Implicated in Epigenetic Signaling Fellowship on Behalf of M. Burns-Cusato Funciton of RVB1-Tip60 in the DNA Damage Response Genetic & Neuroendocrine Control of Behavioral Systems Genetic Control of Mitotic Spindle Assembly & Function Identification & Analysis of HAT/Coactivator Complexes Identification & Characterization of the Factors Responsible for Centrometric Identifying Inhibitors of the APC/C Using Yeast Mutants Inflammatory Cytokines Link NF-kappaB with Bim Degradation and Metastasis Inhibitors of DNA-Dependent ATP Hydrolytic Activity and Associated Functions Interactions of Actin with Dystrophin & Utrophin Investigation of Mechanisms Leading to Anemia at Low Parasite Burden in Children with Malaria Ira Hall Career Award in Biomedical Sciences Isolation of Genes for Radiation Sensitivity Ligand-Induced Control of LXR & FXR in Cholestrol Homeostasis Lung Cancer Promoting Roles of the Hec1/Ndc80 Kinetochore Complex Mapping Replication Elements on Human Chromosomes Mapping Replication Elements on Human Chromosomes Mapping Replication Elements on Human Chromosomes Mechanisms of "End On" Microtubule Attachment by the Kinetochore Mechanisms of rDNA Transcriptional Elongation Mechanisms of rDNA Transcriptional Elongation Mechanisms of rDNA Transcriptional Repression Mechanisms of rDNA Transcriptional Repression Methods for Analysis of Helical Macromolecular Complexes Methods for the Analysis of Helical Macromolecular Complexes MicroRNAs in Differentiation of Muscle MicroRNAs in Differentiation of Muscle MicroRNAs in Differentiation of Muscle MicroRNAs in Prostate Cancer MicroRNAs in Prostate Cancer MicroRNAs in Prostate Cancer Mitotic Regulation of Aurora/IPII Kinases Modulation of NF-kappaB by the SIRTR1 Deacetylase Molecular Analysis of a DNA Repair Complex Molecular Analysis of a DNA Repair Complex Molecular Analysis of a Yeast Transcriptional Regulator Molecular Analysis of a Yeast Transcriptional Regulator Molecular Evolution of Eukaryotes: a protistan emphasis Mutational Analysis of the BRCT Motif in BRCA1 Neurobiology & Development Training Program Neurobiology and Development Training Program Neuroendocrine Control of Feeding and Reproduction Non-Random Chromosome Segregation in Mouse Embryonic Stem Cells Oncogenic Ras Requires NF-kB Antiapoptotic Function p53 and Checkpoint Pathways in Cancer Cell Replication p53 and Checkpoint Pathways in Cancer Cell Replication p53 and Checkpoint Pathways in Cancer Cell Replication PAMUVA Technology - Targeting DNA Metabolic Processes Platelet Adhesion Defects & Bleeding in Uremia Platelet Adhesion to Collagen under Flow Conditions Post-Translational Modification of Centromere Protein Postdoctoral Fellowship on Behalf of J.J. Smith Predoctoral Fellowship on Behalf of J. Lin Predoctoral Fellowship on Behalf of J. Lin Predoctoral Fellowship on Behalf of J. Lin Predoctoral Traineeship on Behalf of J. Sun Proof of Principle in Pathogen Clearance Regulation of Cancer Cell-Cycle by Statins Regulation of Histone Acetylation in Drosophila Replication Control in E. histolytica Replication Control in E. histolytica Replication Control in E. histolytica Replication of Mamalian Chromosomes Replication of Mammalian Chromosomes Reproduction, Nutrition and Behavior Role of CY Motifs in Substrate Recognition by CDKS Role of CY Motifs in Substrate Recognition by CDKS Role of CY Motifs in Substrate Recognition by CDKS Role of IKK in NSCLC: Modulation of SMRT & NF-KappaB Role of KIAA0350 locus in Autoimmunity RUVBL (orTIP49), Partners for the MYC Oncogene in Transformation RUVBL (orTIP49), Partners for the MYC Oncogene in Transformation RUVBL (orTIP49), Partners for the MYC Oncogene in Transformation Screen for TIP60 Inhibitors Screen for TIP60 Inhibitors Screen for TIP60 Inhibitors Sequence Analysis of Salmonella Genomes Sex Chromosome Effects on Neural & Behavioral Differentiation Sex Chromosome Effects on Neural Development Shiga-Toxin Induced Inflammation & Thrombosis Spinocerebellar Ataxia 7 Protein Function Strategies for Mapping Origins in Mammalian Genomes Strategies for Mapping Origins in Mammalian Genomes Structural Basis of Histone Tail Recognition Structural Determinants of Chromodomain Function Structural Determinants of PPAR Alpha Activation by CHD9 Protein Structural Studies of Actin Structural Studies of Actin Structural Studies of Actin Structural Studies of Nucleoprotein Complexes Structural Studies of Nucleoprotein Complexes Structural Studies of the SV40 Large T Antigen Structure Determination of HTLV-I Capsid Protein Studies of the Mechanism of Action of CI-994 Study of the Nuclear IKK Functions Associated to Tumorigenesis Duration 3 The Fate of Duplicated Genes in Model Grass Genomes Aft The Fate of Methylated Histones The Mechanism of BRCA1 in Tumor Suppression The Ribosomal DNA & Transcriptional Silencing The Ribosomal DNA & Transcriptional Silencing Training In Cell & Molecular Biology Transcription Factors in Eukaryotic DNA Replication Using Yeast to Identify the Targets of BRCA1 X-ray Crystallographic Studies of MeCP2 on a Chromatin Substrate Abbas, Tarek A – Post Doctoral Fellow Abel, Jean M – Assistant Professor Abraham, David – Research Associate in Biochemistry & Molecular Genetics Auble, David T – Associate Professor Balian, Gary – Professor Baranova, Natalya N – Research Associate in Biochemistry & Molecular Genetics Bekiranov, Stefan – Assistant Professor Beum, Paul V – Senior Scientist Bhowmick, Bejon K – Research Associate in Biochemistry & Molecular Genetics Bradbeer, Clive – Professor Emeritus Burke, Daniel J – Professor Cho, Woohee – Visiting Research Assistant Chodaparambil, Sanjay V – Research Associate in Biochemistry & Molecular Genetics Concannon, Patrick J – Professor Dey, Bijan Kumar – Post Doctoral Fellow Dutta, Anindya – Byrd Professor Dziegielewska, Barbara – Research Associate of Biochemistry & Molecular Genetics Egelman, Edward H – Professor Farber, Charles R – Assistant Professor Foltz, Daniel R – Assistant Professor Fuller, Brian G – Assistant Professor Galkin, Vitold E – Assistant Professor Gatewood, Jessica Dawn – Research Assistant of Biochemistry & Molecular Genetics Gear, Adrian R – Professor Emeritus Grant, Patrick A – Associate Professor Gupta, Ashish – Research Assistant in Biochemistry & Molecular Genetics Hall, Ira M – Assistant Professor Hamlin, Joyce L – Professor Hockensmith, Joel W – Associate Professor Hook, Sara S – Research Associate in Biochemistry & Molecular Genetics Jha, Sudhakar – Research Associate in Biochemistry & Molecular Genetics Karnani, Neerja – Research Associate in Biochemistry & Molecular Genetics Keaton, Mignon A – Post Doctoral Fellow Khorasanizadeh, Sepideh – Associate Professor Kim, Daesung – Research Associate in Biochemistry & Molecular Genetics Lalmansingh, Anika Ayo – Research Associate in Biochemistry & Molecular Genetics Li, Duo – Research Associate in Biochemistry & Molecular Genetics Li, Mingguang – Research Associate in Biochemistry & Molecular Genetics Lindorfer, Margaret A – Assistant Professor Liu, Limin – Post Doctoral Fellow Louie, Sarah H – Research Associate of Biochemistry & Molecular Genetics Lynch, Kevin R – Professor Matecic, Mirela – Research Associate in Biochemistry & Molecular Genetics Mayo, Marty W – Associate Professor Mesner, Larry D – Asst Prof Moore, Michael L – Research Associate in Biochemistry & Molecular Genetics Nakamoto, Robert K – Professor Nitcher, Sara E.R. – Research Associate in Biochemistry & Molecular Genetics Noramly, Selina – Assistant Professor Orlova, Albina A – Senior Scientist Park, Jin Ho – Research Associate in Biochemistry & Molecular Genetics Park, Jong Hoon – Research Associate of Biochemistry & Molecular Genetics Paschal, Bryce M – Professor Pearson, William R – Professor Pickin, Rebecca R – Research Associate in Biochemistry & Molecular Genetics Pray-Grant, Marilyn G – Research Scientist Quinlan, Aaron R – Post Doctoral Fellow Rastinejad, Fraydoon – Professor Rissman, Emilie F – Professor Sale, Michele – Associate Professor Sarkar, Sukumar – Research Associate in Biochemistry & Molecular Genetics Shi, Weibin – Associate Professor Shibata, Etsuko – Research Associate in Biochemistry & Molecular Genetics Shibata, Yoshiyuki – Research Associate in Biochemistry & Molecular Genetics Smith, Jeffrey S – Associate Professor Solodukhin, Alexander S – Research Scientist Stolzenberg, Danielle s – Post Doctoral Fellow Stukenberg, Peter Todd – Professor Taylor, Ronald P – Professor Terai, Kenta – Research Associate in Biochemistry & Molecular Genetics Teraoka, Sharon – Assistant Professor Valsakumar, Veena – Research Assistant of Biochemistry and Molecular Genetics Wen, Jie – Research Associate in Biochemistry & Molecular Genetics Wolstenholme, Jennifer T – Research Associate in Biochemistry & Molecular Genetics Wotton, David – Associate Professor Xu, Xiaojiang – Research Associate in Biochemistry & Molecular Genetics Yu, Sean Xiong – Assistant Professor Related News: |
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