Department of Molecular Phys and Biological Physics |
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The major missions of the department are to conduct interdisciplinary research with the aim of discovering physiological mechanisms and their pathological aberrations resulting in disease and to teach medical and graduate students and postdoctoral fellows in a modern, inspiring, and cost effective manner. The Department among the top NIH ranked Physiology departments in the country and aims to achieve excellence reflected by high impact publications, peer reviewed research support, international recognition of the faculty and excellence and success of academic and practicing physicians and scientists trained. A related goal of the Department is to provide a focus for structural biology at the University of Virginia, and to be a major force in facilitating translational research in collaboration with Clinical and other Basic Science Departments and through interactions with National Laboratories and industrial entities. Major areas of research are cardiovascular (smooth and cardiac muscle) physiology, membrane proteins and signal transduction in normal and cancer cells.
Faculty members use X-ray crystallography, both in our crystallographic laboratory and at international synchrotron centers, for studies of proteins regulated by or regulating the small GTPase, Rho pathways of signal transduction, enzymes involved in lipid metabolism, membrane channels and protein phosphatases. The only biological cryo-atomic force microscope in the world was designed and built in the department and provided high-resolution information about the structure of myosin, toxins, lipid bilayers and chaperon molecules. Other laboratories are developing and utilizing electron paramagnetic resonance (EPR) for studies of ion channels, nuclear magnetic resonance (NMR) spectroscopy for determining transcription factor structures, total internal reflectance fluorescence microscopy (TIRFM) and vibrational spectroscopy (ATR-FTIR) for the study of membrane channels, lipid-protein interactions and protein dynamics. A 200 kV electron microscope equipped with field emission gun and electron spectrometer and X-ray detector is used for studies of the subcellular composition of cardiac and vascular smooth muscle and for developing electron energy loss spectroscopic (EELS) imaging. Confocal immunofluorescence microscopy is used routinely for studies of signaling cellular pathways. Contact: PO Box 801398 Charlottesville, VA 22908-1398 Phone: 434-924-5108 Fax: 434-982-1616 Website: http://www.healthsystem.virginia.edu/internet/physio/ |
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projects | faculty | news |
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Projects By Department of Molecular Phys and Biological Physics: 800 MHz NMR Spectrometer for High-End NMR Structural Studies A Directed Approach to Membrane Protein Crystallography A Force Measuring Apparatus For The Study of Intermolecular Interactions
A Novel Approach to the Development of Highly Specific Inhibitors of EFG Al-Shawi Mechanism of Drug Transport Center for Structural Genomics of Infectious Diseases Combinatorial Biology & the Mitomycin Pathway Derivation of Smooth Muscle Lineages from Stem Cells Determination of the Quatemary Structure of the NA, K-A Development of Beamline Software for High Performance Data Collection Development of Beamline Software for High Performance Data Collection and Analysis on the SBC Beamlines Development of Low Temperature AFM/Freeze Fracture and Etch Development Of Smooth Muscle Myosin Heavy Chain DNA Low-Frequency Internal Vibrations Effects of Anesthetics on Ion-Transporting Atpases Engineering Protein for Cristallization Engineering Protein. Derewenda Etiology of Treatment induced Secondary Leukemia Feasibility Studies of Non-Contact CryoAFM for High Resolution Biological Imaging Fellowship on Behalf of A.S. Kwok Generation of Membrane Protein Production Strains Genomic Mapping of Replication Origins in Higher Eukaryotes by Okazaki Analysis High Resolution Structural Dynamics of K Channels High-Resolution Structural Studies of K+ Channel Pore Implementation of High Performance Data Improved Methods for Membrane Protein Crystallization Improvements of High Performance Data Collection & Analysis NIH Beam Line X9b Insertion/Folding of Polyoptic Integral Membrane Proteins Intercellular Communication in Microvessels International Conference-Structural Mechanisms in Muscle Length Dependence of Force Generation in Cardiac Muscle Linking Funcitons of the FOF1 Synthase Local Regulation Of Microvascular Function MD-MPHY Development of Novel Drugs for MLL-related Pediatric Leukemias Mechanism of Drug Transport by P-Glycoprotein Mechanism of Inv(16) Mediated Leukemogenesis Mechanisms of Lipid-Mediated Signal Transduction Mechanisms of Nitric Oxide-induced Vasodilation Mechanisms Underlying TGF-Beta Induced Vascular Smooth Muscle Cell Differentiation and Phenotypic Modulation Mechanisms Underlying Time-Course of Transmitter Releas Membrane Protein Crystallization Screens Membrane Protein Structural Genomics Pilot Project Membrane Protein Structural Genomics: M Tuberculosis Midwest Center for Structural Genomics Midwestern Center for Structural Genomics Minor.Argonne Integration of HKL-2000_ph Minor.Argonne.Integration of HKL-2000_ph Travel Molecular Architecture of Potassium Channels Molecular Interactions in G Protein Coupled Signaling Molecular Mechanisms of Decreased Smooth Muscle Differentiation Marker Expression Associated with the Pathophysiology of Atherosclerosis Molecular Mechanisms of Neuronal Migrations Molecular Mechanisms of Viral Membrane Fusion Molecular Mechanisms of Viral Membrane Fusion Molecular Regulation of Smooth Muscle Differentiation Mouse Models for Familial Platelet Disorder NM23 & Signal Transduction NMR Structural Studies of CBFA Runt Domain DNA Complex NMR Structural Studies of CBFB & CBFB-SMMHC NMR Structural Studies of Core Binding Factor NO-cGMP Inhibition of Urogenital Smooth Muscle Peripheral Benzodiazepine Receptor Structural Biology Postdoctoral Fellowship on Behalf of S. Chakrapani Preparation of Membrane Protein Crystals Diffracting to High-Resolution Protein Structure & Thermodynamics in Cell Regulation Quantitative Study of Facilitated Neurosecretion Quantitative Study Of Presynaptic Facilitation Rapid Protein Crystallization by Surface Mutagenesis Regulation of Smooth Muscle Myosin Gene Expression Rock Inhibitors Project Role of Moxl, Mizl, and Basic Helix-Loop-Helix Proteins in the Control of Smooth Muscle Differentiation Signal Transduction In Smooth Muscle Single Molecule Studies of Replication Origin in Metazoa Solution NMR Structure & Function of the Integral Membrane Protein DsbB Solution NMR Structures of Integral Membrane Proteins Southeast Regional Collaborative Access Team (SER-CAT): Year 2 Operations-Implementation of HKL2000 Software on SER-CAT Beam Line at Argonne Structural Biology of AML1 (CBFA2) and AML1-ETO Structural Biology of Bacterial Cobalamin Transport Structural Biology of Cancer Related Membrane Proteins Expressed in P. Pastoris Structural Biology of Cardiovascular Proteins Structural Biology of Cardiovascular Signaling Structural Biology of the Human Copper Transporter Ctr1 Structural Dynamics of Mechanosensitive Channels Structural Dynamics of Mechanosensitive Channels Structural Dynamics of Presynaptic Membrane Fusion Structure & Folding of Integral Membrane Proteins Structure & Folding of Integral Membrane Proteins Structure & Function of the Repression Domain of CBFB Structure & Thermodynamics in Domain Interactions of RhoGEFs Structure Analysis of Integrin Activation Structure Analysis of Viral Assembly Mechanisms Structure Biology Center for HIV/Host Interactions in Trafficking & Assembly Structure of a Carrier Potassium Channel Structure-function Analysis of H. pylori Vac A Structure-Function Relationships in Merlin, the Product of the NF2 Causal Gene Targeted Drug Development Against the CBFB-SMMHC Oncoprotein Targeted Inhibition of Oligomeric Translocation Products in AML & CML The Integrated System for Fast Structure Solutions Theoretical Analysis Of Dna Low-frequency Phonon Thioesterase IIH-A Novel Protein in HIV Infectivity TonB-Dependent Outer Membrane Transport Transcriptional Regulation of Runx Proteins in Development & Leukemia Transport of Vitamin B12 in E.Coli X-Ray Crystallography of Human Aquaporin Water Channels X-ray Crystallography of Macromolecules X-ray Crystallography of Macromolecules X-Ray Crystallography of Macromolecules Al-Shawi, Marwan K – Associate Professor Artamonov, Mykhaylo V – Research Associate of Molecular Physiology & Biological Physics Bennett, Brad C – Research Associate of Molecular Physiology & Biological Physics Bushweller, John H – Professor Cafiso, David S – Professor Chruszcz, Maksymilian – Instructor Columbus, Linda – Assistant Professor Cooper, David R – Instructor Corpora, Takeshi A – Research Associate of Molecular Physiology & Biological Physics Cymborowski, Marcin T – Research Assistant in Molecular Physiology and Biological Physics Czajkowsky, Daniel M – Research Associate of Molecular Physiology & Biological Physics Daniels, Mark J – Assistant Professor Derewenda, Urszula – Assistant Professor Derewenda, Zygmunt S – Professor Dryden, Kelly – Assistant Professor Duling, Brian R – Professor Edrington, Thomas C – Research Associate of Molecular Physiology & Biological Physics Etter, Elaine F – Research Associate of Molecular Physiology & Biological Physics Faham, Salem – Assistant Professor Font, Jose – Volunteer Franke, Aaron S – Research Associate of Molecular Physiology and Biologicl Physics Galkin, Mikhail A – Research Associate of Molecular Physiology & Biological Physics Ganser-Pornillos, Barbie K – Assistant Professor Gong, Shimei – Research Associate of Molecular Physiology & Biological Physics Grabowski, Marek – Research Associate of Molecular Physiology & Biological Physics Hackett, John T – Professor Hall, Jennifer – Visiting Research Associate Hedrick, Catherine C – Visiting Professor Ho, Ruoya – Assistant Professor Horanyi, Peter S – Research Associate of Molecular Physiology & Biological Physics Illendula, Anuradha – Instructor of Research Isakson, Brant – Assistant Professor Khromov, Alexander S – Assistant Professor Kiessling, Volker – Assistant Professor Klimecka, Maria M – Research Associate of Molecular Physiology & Biological Physics Kutchai, Howard C – Professor & Acting Chair of Molecular Physiology & Biol Phys Kwok, Alfred – Visiting Research Associate Laubach, Victor E – Associate Professor Ley, Klaus F – Professor Liang, Binyong – Assistant Professor Linden, Joel M – Professor Mcnamara, Coleen A – Professor Minor, Wladek – Professor Momotani, Ko – Instructor Nakamoto, Robert K – Professor Owens, Gary K – Professor Peskova, Yelena – Research Associate of Molecular Physiology & Biological Physics Pornillos, Owen Wilbert – Assistant Professor Purdy, Michael D – Instructor Roy, Ankoor – Research Associate in Molecular Physiology & Biological Physcis Shao, Zhifeng – Professor Shumilin, Igor A – Instructor Shupnik, Margaret A – Professor Somlyo, Avril V – Professor Srimath Tirumala, Venkata Sesha – Research Associate of Molecular Physiology & Biological Physics Szabo, Gabor – Professor Emeritus Tamm, Lukas K – Professor Theodorescu, Dan – Professor Trentham, David R – Visiting Professor Tucker, Amy L – Associate Professor Utepbergenov, Darkhan – Research Associate of Molecular Physiology & Biological Physics Wamhoff, Brian R – Assistant Professor Wiener, Michael C – Associate Professor Yeager, Mark – Professor Zheng, Heping – Research Associate of Molecular Physiology & Biological Physics Zhou, Yunpeng – Research Associate of Molecular Physiology & Biological Physics Zimmer, Jochen – Assistant Professor Zimmerman, Matthew D – Research Associate of Molecular Physiology & Biological Physics Related News: |
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