Department of Neuroscience

A Non-secreted form of IGF-1 is a Protective Factor for Neural Stem Cells
Scrable, Heidi. Sponsor: U.S. National Institute On Aging

A Potential New Therapy for Stroke
Lee, Kevin S. Sponsor: Cortex Pharmaceuticals, Inc.

Career Award in the Biomedical Sciences
Liu, Jeh-Ping (Serena). Sponsor: Burroughs Welcome Foundation

CNS Plasticity of Human Adipo-Derived Multipotent Cells
Lee, Kevin S. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Stem cells and regenerative cell therapies hold great promise for treating a variety of disorders; however, an optimal cell source for translating this promise into the clinical realm remains to be determined. ...

Compensating for Environmental Change in the Neural Coding of Behavior
Worden, Mary K. Sponsor: Jeffress Memorial Trust

Construction of a Transgenic Mouse with Conditional HD
Scrable, Heidi. Sponsor: Hereditary Disease Foundation

Control of Hox Gene Expression and Neuronal Identity
Liu, Jeh-Ping (Serena). Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Distinct types of neurons are generated at specific locations during development of the central nervous system. These neurons then connect precisely with their targets to form a functional neural network. ...

Delayed Tolerance After Hypothermic Preconditioning
Lee, Kevin S. Sponsor: U.S. National Institutes Of Health
Ischemic injury is a common complication in a wide range of surgical procedures. Hypothermia administered during and/or after an ischemic event has proven to be clinically beneficial, and its effects ...

Detrol & Alzheimer's Disease Neuropathology
Tuttle, Jeremy B. Sponsor: Pfizer Pharmaceutical Labs.

Development of a New Treatement Regimen for Copaxone in a Mouse Model of Relapsing/Remitting EAE
Kipnis, Jonathan. Sponsor: Montel Williams MS Foundation

Development of Transgenic Mouse
Scrable, Heidi. Sponsor: University Of California at Los Angeles

Effects of Gamma Knife Radiosurgery in Animal Mode
Lee, Kevin S. Sponsor: Elekta Instruments Inc.

Epileptogenesis in a rat model of Cortical Malformations
Lee, Kevin S. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

Fellowship on Behalf of E.K. Ungewitter
Scrable, Heidi. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

Fellowship on Behalf of M. Burns-Cusato
Scrable, Heidi. Sponsor: U.S. Nih Of Child Health & Human Development

Fellowship on Behalf of Z. Hu
Corwin, Jeffrey T. Sponsor: National Organization for Hearing Research

Forebrain Organization in a Novel Rat
Lee, Kevin S. Sponsor: U.S. National Heart, Lung, And Blood Institute
Malformations of the cerebral cortex are present in over 1 percent of the general human population and at least 20 - 40 percent of intractable epileptics. Increasing evidence implicates misplaced cortical ...

Functional Development of Hair Cells
Geleoc-Holt, Gwenaelle S. Sponsor: U.S. Nih Deafness & Other Communication Disorders

Gene Expression Changes in the Aging HPF Axis
Scrable, Heidi. Sponsor: Virginia Commonwealth University

Generation of a Knockin Mouse Model Expressing 140Q-Huntingtin
Zeitlin, Scott O. Sponsor: Hereditary Disease Foundation

Genetic Models to Chart the Course of Aging in the Mouse
Scrable, Heidi. Sponsor: The Ellison Medical Foundation

Growth & Regeneration in the Inner Ear
Corwin, Jeffrey T. Sponsor: U.S. Nih Deafness & Other Communication Disorders

Growth and Regeneration in the Inner Ear
Corwin, Jeffrey T. Sponsor: U.S. Nih Deafness & Other Communication Disorders
It is estimated that 80 percent of significant hearing impairment in the U.S. is sensorineural or "nerve" deafness that usually originates from hair cell losses. Deficits in the sensory hair cells that ...

Hair Cell Development in the Mouse Embryo
Geleoc-Holt, Gwenaelle S. Sponsor: U.S. Nih Deafness & Other Communication Disorders
It has been estimated that one out of every thousand children is born with significant hearing and/or balance impairment. A substantial portion of these congenital disorders are sensorineural in origin, ...

Identification of the Molecular Basis of Sensory Signaling in the Ear
Holt, Jeffrey R (Jeff). Sponsor: Carman Trust

Inflammation and Cerebral Vasospasm: New Perspectives
Lee, Kevin S. Sponsor: Virginia Heart Association

Ion Channel Function in Auditory & Vestibular Hair Cells
Holt, Jeffrey R (Jeff). Sponsor: U.S. Nih Deafness & Other Communication Disorders
The studies proposed here focus on the function of KCNQ potassium channels in the sensory hair cells of the auditory and vestibular systems. Mutations in four of the five members of this newly discovered ...

Ion Channel Function in Auditory & Vestibular Hair Cells
Holt, Jeffrey R (Jeff). Sponsor: U.S. Nih Deafness & Other Communication Disorders

Keck Foundation Distinguished Young Scholars Award
Holt, Jeffrey R (Jeff). Sponsor: Keck Foundation

LAC Repressor Mouse
Scrable, Heidi. Sponsor: U.S. National Center For Research Resources
The goal of the research proposed in this application is control of the endogenous mouse genome by elements derived from the lac operon of E. coli. It is a direct extension of the goal of the applicants' ...

Loss-of-Function Mechanisms in Huntington's Disease
Zeitlin, Scott O. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Huntington's disease (HD) is a dominant hereditary neurodegenerative disease that is caused by the expansion of a stretch of CAG repeats within the HD gene that encodes a large protein (huntingtin; htt) ...

Loss-of-Function Mechanisms in Huntington's Disease
Zeitlin, Scott O. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

MD-NESC Effects of Bladder Control Medication on Beta-Amyloid Peptide Metabolism
Tuttle, Jeremy B. Sponsor: U.S. National Institute On Aging

ME-NESC Induction of Tolerance with Trans-Sodium Crocetinate
Lee, Kevin S. Sponsor: Diffusion Pharmaceuticals LLC

Mechanisms of Cell Specific Death in Huntingtons Disease
Scrable, Heidi. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

Molecular Basis of Hippocampal Learning
Scrable, Heidi. Sponsor: Jeffress Memorial Trust

Molecular Mechanisms of Neurodegeneration in Alzheimer's Disease
Onyango, Isaac G. Sponsor: Virginia Commonwealth University

Myosin I-Beta and Inner Ear Structure and Function
Holt, Jeffrey R (Jeff). Sponsor: THE MCLAUGHLIN RESEARCH INSTITUTE

Neurofascin as an Immune Target for Peripheral Neuropathy
Winckler, Bettina. Sponsor: Jeffress Memorial Trust

Neuroimmunology Seminar Series
Kipnis, Jonathan. Sponsor: TEVA Neuroscience, Inc.

Neurological Impact of Cardiopulmonary Bypass Surgery
Lee, Kevin S. Sponsor: U.S. Nih Of Neurological Disorders & Stroke

Neuronal Cell Signaling & Apoptosis in Alzheimer's Disease
Onyango, Isaac G. Sponsor: Alzheimer's Disease Association

Neuronal Cell Signaling & Apoptosis in Alzheimer's Disease
Bennett, James P JR. Sponsor: Virginia Commonwealth University

Novel Therapeutic Interventions in Traumatic Brain Injury
Lee, Kevin S. Sponsor: Department Of Rehabilitation Services

Predoctoral Fellowship on Behalf of J.r. Risner
Holt, Jeffrey R (Jeff). Sponsor: U.S. Nih Deafness & Other Communication Disorders

Predoctoral Training in Neuroscience
Lee, Kevin S. Sponsor: U.S. National Institute Of General Medical Science

Predoctoral Training in Neuroscience
Lee, Kevin S. Sponsor: U.S. National Institute Of General Medical Science

Predoctoral Training in Neuroscience
Lee, Kevin S. Sponsor: U.S. National Institute Of General Medical Science

Predoctoral Training in Neuroscience
Lee, Kevin S. Sponsor: U.S. National Institute Of General Medical Science

Spatial & Temporal Control of the Mouse Genome by LAC
Scrable, Heidi. Sponsor: U.S. National Institute On Aging
The overall goal of this proposal is the genome-wide spatial and temporal regulation of murine gene expression by the lac operator-repressor system. Our modified system is already being used to regulate ...

Stem Cells & Repair in Auditory & Vestibular Systems
Corwin, Jeffrey T. Sponsor: U.S. Nih Deafness & Other Communication Disorders
Millions of Americans are affected by permanent hearing deficits and balance dysfunctions that result from losses of sensory hair cells. In mammalian ears, when hair cells die they are not effectively ...

Targeting Pathways of Axonal Cell Adhesion Molecules
Winckler, Bettina. Sponsor: U.S. Nih Of Neurological Disorders & Stroke
Proper functioning of all cell types depends on correctly targeting a large number of proteins to specific cellular sites of action, incorrect protein targeting has been linked to a variety of disease ...

The Sir2-p53-IGF Link in Mammalian Life-Span Control
Scrable, Heidi. Sponsor: U.S. National Institute On Aging

Therapeutic Effect of EMFS on Neural Processes/Function
Tuttle, Jeremy B. Sponsor: U.S. Nih For Complimentary & Alternative Medicine
Magnetic devices and therapies are gaining rapid acceptance among some groups, even in the absence of reliable outcome data. This Center is focused upon the potential treatment with electromagnetic fields ...

Utility of a Novel Carotenoid for Treating Stroke
Lee, Kevin S. Sponsor: U.S. Nih Of Neurological Disorders & Stroke