Department of Pharmacology |
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The Department of Pharmacology is one of six basic science Departments within the School of Medicine at the University of Virginia. Its faculty includes scientists with a diverse range of research interests drawing from the established scientific disciplines of chemistry, biology, physics and engineering. Traditionally, Pharmacology has been considered an applied science. However, with the development of biological chemistry, molecular biology, structural biology, neuroscience, and electrophysiology, Pharmacology has become a diverse science that probes basic mechanisms of molecular and cellular function with the knowledge that unraveling these mechanisms will lead to new therapeutic approaches to a variety of diseases. The Department of Pharmacology, therefore, has a unique role within the basic biomedical sciences, to conduct investigations into the fundamental principles of cell function and translate these findings to clinical applications.
Because novel approaches to drug development require a new and comprehensive understanding of cellular organization and communication, the mechanisms by which cells transmit signals within and among cells is an area of emphasis within the Department. The Department of Pharmacology at the University of Virginia has a distinguished scientific history in the study of cellular signaling processes (signal transduction); two recent Nobel Laureates honored for their work deciphering pathways of cellular signaling conducted this work in the Pharmacology Department at the University of Virginia. Today, faculty of the Department of Pharmacology bring to bear a wide range of scientific approaches and technical methods to address fundamental questions of cellular signaling related to neural transmission, hormone and growth factor signaling, cell cycle regulation, neoplasia and regulation of gene expression. This theme unites faculty whose research focus on: receptor characterization, regulation of protein kinase and phosphatase cascades, proteonomics, ion channel regulation, structural analysis of DNA binding proteins, translational control of protein synthesis, extracellular matrix signaling, gene expression, and mathematical modeling of hormone release. Contact: PO Box 800735 Charlottesville, VA 22908-0735 Phone: 434-924-1919 Fax: 434-982-3878 Website: http://www.healthsystem.virginia.edu/internet/pharmacology/ |
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projects | faculty | news |
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Projects By Department of Pharmacology: Aberrant Synaptic AMPA-R Trafficking in MECP2 Knockout Mice Anesthetic Action of Ketamine Involve Inhibition of Pacemaker Current (Ih) Anesthetic Action: Channels Substrates & Mechanisms Anesthetic Action: Channels Substrates & Mechanisms Annexin Phosphorylation: Causes & Consequences Calcium Dependent Membrane Binding Proteins Cellular/Molecular Mechanisms of GIRK Channel Inhibition Center for Fluorescence Spectroscopy Center for Fluorescence Spectroscopy Central Mechanisms Underlying the Restoration of Arteri Central Neural Function of Urocortin 3 in Regulating Energy Balance Central Neuronal Mechanisms -- Decompensated Hemorrhage Cloning & Expression of Cardiac T Type CA Channel Dev. Of Brainstem Neurotransmitter Development of High Throughput Assays for HVA CA Channels Development of Novel Antiepileptic Drugs Distance Distribution & Dynamics Of Macromolecules Establishment of Functional Neuronal Communication during Development FMRP Regulates Small GTPase Ras Signaling & Glutamate Receptor Trafficking Functional Neuroanatomy of the Pre-Botzinger Complex FXR Interactions with Ligands & Coregulators G-Protein Regulation of the Phosphatidyl Inositol (3, 4, 5) Trisphosphate Signal Gaq Signaling in Neurons: Novel Mechanisms and Targets Generation of mutant mice HTS Assays for Specific Modulators of Neuronal Acid-Sensitive K+ Channels Identification of 100 Proteins & Peptides by Edman Indetification of Novel Drug Targets for Breast Cancer Insulin Action in Muscle & Fat Cells Insulin Action in Muscle and Fat Cells Integration of Brainstem Adrenergic & Noradrenergic Interactions of C2 Domain & Annexins with Lipid Bilayer Intercellular Signaling - Core B Leak Potassium Channels in Striatal Cholinergic Neurons Mechanism of Action of Lipin Mechanism of Phospholipase C-gamma1 Activation Mechanisms and Site of Ventilatory Neurogenesis Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways Molecular Analysis of L-Type Calcium Channel Regulation Molecular Analysis of Neuronal T Type CA++ Channels Molecular Pharmacology of Sphingosine 1-Phosphate Molecular Recognition in Steroid Signaling Motor Denervation, Muscle Atrophy, & Insulin MTOR Signaling Pathway mTOR Signaling Pathways NF1-Ras Signaling and Synaptic AMPA-R Trafficking Nuclear Receptors Interactions on DNA Direct Repeats Oncogenic Ras Signaling at Synapses Organization of Central Sympathetic Pathways Postdoctoral Fellowship on Behalf of C. Hu Postdoctoral Fellowship on Behalf of D.K. Mulkey Postdoctoral Fellowship on Behalf of L.A. Davies Regulation & Function of MAPKAP Kinases Regulation & Function of MAPKAP Kinases Regulation of Cell Signaling by G Protein by Subunits Regulation of Cell Signaling by G Protein by Subunits Retrotrapezoid Nucleus and Central Chemoreception Signaling Pathway Underlying Synaptic Depression Induced byb-Amyloid-Protein Software for the Analysis of Hormone Pulsatility Sponsored Research Agreement Structural Basis Of Ganglioside Recognition Structure Of Inositol Glycan Mediator & Inositol G Structure-Based Design of Androgen Receptor Antagonists Structure/function Studies Of Androgen Receptor Dn Synapse-Specific Regulation of Transmission & Integration in the Barrel Cortex T Type Calcium Channels & Aldosterone Secretion T-Type CA2+ Channels & Aldosterone Secretion T-Type CA2+ Channels & Aldosterone Secretion TASK Channel Modulation Via G Protein-Coupled Receptors The Effect of G Protein bg Subunit Composition on T-Lymphocyte Function as Mediated by the Adenosine A2a & S1P Receptors Training Fellowship on Behalf of J. Baumgart Training in the Pharmacological Sciences Two-Pore Domain Potassium Channels & Aldosterone Secretion Upstate Biotechnology Urocortin III: Regulation & Function in the Islet Barrett, Paula Q – Professor Bayliss, Douglas A – Professor Biltonen, Rodney L – Professor Emeritus Blythe, Sarah N – Post Doctoral Fellow Bochorishvili, Genrieta – Research Associate in Pharmacology Chandra, Vikas – Instructor Chen, Xiangdong – Assistant Professor Choi, Kyouchan – Research Assistant of Pharmacology Creutz, Carl E – Professor Depuy, Seth D – Post Doctoral Fellow Du, Guizhi – Research Associate in Pharmacology Garrison, James C – Professor Geysen, Hendrik M – Professor Guagliardo, Nick A – Instructor Guyenet, Patrice G – Professor Harris, Thurl E – Assistant Professor Hedrick, Catherine C – Visiting Professor Hewlett, Erik – Professor Hoehn, Kyle L – Assistant Professor Hu, Changlong – Research Associate in Pharmacology Jiang, Xiaolong – Research Associate in Pharmacology Johnson, Michael L – Professor Kanbar, Roy – Visiting Research Associate Ke, Jiangbin – Research Associate of Pharmacology Kharel, Yugesh – Instructor Kim, Hyun Bae – Research Associate in Pharmacology Laxman, Anil Kumar K – Instructor Lazarenko, Roman – Research Associate in Pharmacology Leitinger, Norbert – Associate Professor Li, Chien – Assistant Professor Lim, Chae Seok – Research Associate in Pharmacology Linden, Joel M – Professor Lynch, Kevin R – Professor Macdonald, Timothy L – Professor Mcintire, William E – Assistant Professor Nadler, Jerry L – Visiting Professor Perez-Reyes, Deborah L – Research Assistant Perez-Reyes, Edward – Professor Potter, James Douglas – Professor Rastinejad, Fraydoon – Professor Rosin, Diane L – Assistant Professor Schulman, Ira G – Associate Professor Shi, Yingtang – Research Associate of Pharmacology Stornetta, Ruth L – Associate Professor Strauss, Philip Bradford – Administrative Director Sturgill, Thomas W – Professor Tomsig, Jose L – Instructor Vitko, Iuliia – Instructor Wang, Guangfu – Research Associate of Pharmacology Wang, Lifu – Instructor Yan, Zhen – Associate Professor Yao, Junlan – Instructor Zhang, Lei – Research Associate in Pharmacology Zhang, Wei – Research Associate of Pharmacology Zhu, Jun J – Associate Professor Related News: |
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